Bibliographic Details
| Title: |
Is antipsychotic augmentation associated with improved functioning in patients on clozapine? |
| Authors: |
Cho, Jae Hee1 (AUTHOR) JaeHee.Cho@health.nsw.gov.au, Mukherjee, Hindol2 (AUTHOR), Sazhin, Vladimir1 (AUTHOR) |
| Source: |
Australasian Psychiatry. Jun2024, Vol. 32 Issue 3, p186-191. 6p. |
| Subject Terms: |
*CLOZAPINE, *ANTIPSYCHOTIC agents, *REHABILITATION centers, *PSYCHIATRIC hospitals, *LIFE skills |
| Abstract: |
Objective: We aimed at exploring the relationship between functional outcomes in patients on clozapine augmented with antipsychotics in treatment-resistant schizophrenia using standard outcome measures Health of Nation Outcome Scales (HoNOS) and Life Skills Profile (LSP-16). Method: In a cross-sectional study of 83 patients on clozapine treated in a psychiatric rehabilitation hospital, the association between the primary outcome measure, LSP-16 including its subscales, and treatment with antipsychotic augmentation (AA) were analysed using linear regression. Result: The presence of moderate-to-severe positive symptoms on the HoNOS 6 dichotomised item measure was the only statistically significant predictor of functional impairment as determined by total LSP-16 score. The group of patients with ongoing positive symptoms (partial responders) were characterised by higher total LSP-16 scores, higher numbers of AA agents, and higher chlorpromazine equivalence. There was an inverse linear relationship between chlorpromazine equivalence of AA and total score of LSP-16 scale in the group of partial responders. Conclusion: Augmentation with other antipsychotic agents was associated with higher functioning in a cross-sectional study of patients with schizophrenia with poor response of positive symptoms to clozapine. This might be an important clinical factor to consider when prescribing antipsychotics to patients with clozapine-resistant schizophrenia. [ABSTRACT FROM AUTHOR] |
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