Bibliographic Details
| Title: |
Risk factors for sulfamethoxazole/trimethoprim‐induced severe cutaneous adverse reactions. |
| Authors: |
Pinyopornpanish, Kanokkarn1,2 (AUTHOR), Chungcharoenpanich, Apinya1 (AUTHOR), Teepapan, Putthapon1 (AUTHOR), Thadanipon, Kunlawat3,4 (AUTHOR), Ruangwattanachok, Chulapha5 (AUTHOR), Lamrahong, Pansa5 (AUTHOR), Thongdee, Nattakirana1 (AUTHOR), Dechapaphapitak, Nizchapa1 (AUTHOR), Sukasem, Chonlaphat6,7,8,9,10,11 (AUTHOR), Pongphaew, Chanamon12 (AUTHOR), Jantararoungtong, Thawinee6,7 (AUTHOR), Koomdee, Napatrupron6,7 (AUTHOR), Laisuan, Wannada1 (AUTHOR) wannada.lai@mahidol.ac.th |
| Source: |
Clinical & Experimental Allergy. May2024, Vol. 54 Issue 5, p366-368. 3p. |
| Subject Terms: |
*STEVENS-Johnson Syndrome, *T cell receptors, *HLA histocompatibility antigens |
| Abstract: |
This article discusses the risk factors for sulfamethoxazole/trimethoprim (SMX/TMP)-induced severe cutaneous adverse reactions (SCARs). The study found that the HLA-B*13:01 allele is significantly associated with SMX/TMP-induced drug reaction with eosinophilia and systemic symptoms (DRESS). Additionally, a higher daily dose of SMX/TMP was identified as a risk factor for SMX/TMP-induced SCARs. The study suggests that HLA-B*13:01 could be used as a predictive marker for identifying individuals at risk of developing DRESS after SMX/TMP treatment. However, further research is needed to validate these findings and determine the clinical utility of HLA gene testing in predicting adverse reactions to SMX/TMP. [Extracted from the article] |
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