Bibliographic Details
| Title: |
Prevalence of Autoimmune Thyroiditis and Other Autoimmune Diseases in Relation to Serum BAFF/APRIL Levels in Prolactinoma Patients. |
| Alternate Title: |
Prolaktinoma Hastalarında Serum BAFF/APRIL Düzeyleriyle İlişkili Olarak Otoimmün Tiroidit ve Diğer Otoimmün Hastalıkların Prevalansı. |
| Authors: |
Meletli, Özlem Kanburoğlu1, Altınova, Alev2, Bolayır, Başak2, Karakuş, Resul3, Coşkun, Meriç2 drmericcoskun@gmail.com, Yalçın, Mehmet Muhittin2, Aktürk, Müjde2, Yetkin, İlhan2, Toruner, Füsun Saadet2 |
| Source: |
Gazi Medical Journal. 2024, Vol. 35 Issue 1, p12-18. 7p. |
| Subject Terms: |
*AUTOIMMUNE thyroiditis, *TALL-1 (Protein), *VITAMIN B12 deficiency, *THYROIDITIS, *AUTOIMMUNE diseases, *PROLACTINOMA, *THYROID gland function tests |
| Abstract (English): |
Objective: There may be an association between hyperprolactinemia and autoimmune diseases, possibly because of the immunostimulatory effect of prolactin. The aim of this study was to investigate the prevalence of thyroid and non-thyroid autoimmune diseases, serum B-cell activating factor (BAFF), and proliferation-inducing ligand (APRIL) levels as indicators of increased autoimmunity, quality of life, depression, and anxiety in patients with prolactinoma. Methods: Fifty-six premenopausal women with prolactinoma and 50 healthy premenopausal women were included in the study. Autoimmune markers, including anti-nuclear antibody, rheumatoid factor immunoglobulin M (IgM) (RF-IgM), anti-double-stranded DNA (anti-dsDNA), anti-transglutaminase IgA (anti TG-IgA), and anti-Sjogren's syndrome A (anti-ssA), serum BAFF, APRIL and vitamin B12 levels, thyroid function tests, anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin and thyroid Doppler ultrasound, were evaluated. Short-form 36, Beck Depression Inventory, and Beck Anxiety Inventory tests were also used. Results: The prevalence of autoimmune thyroiditis (AIT) was 32.1% in the patient group, whereas the prevalence of newly diagnosed AIT was similar to controls (p>0.05). Vitamin B12 deficiency was higher in patients with prolactinoma than in controls (25.6% and 9.1%, p=0.016). Autoantibody positivity was found to be similar between the groups (35.7% and 28.1%, p=0.25). Serum BAFF and APRIL levels were not different in patients with prolactinoma than in controls (p>0.05). Quality of life, anxiety, and depression scores were not different between patients with or without AIT and those with or without positivity for any autoantibody (p>0.05). Conclusion: One-third of the patients were diagnosed with AIT and onefourth of the patients had vitamin B12 deficiency in our study. However, non-thyroid autoimmune diseases did not increase and no alterations were detected in serum BAFF/APRIL levels in patients with prolactinoma. [ABSTRACT FROM AUTHOR] |
| Abstract (Turkish): |
Amaç: Prolaktinin immün sistemi uyarıcı etkisi nedeniyle hiperprolaktinemi ile otoimmün hastalıklar arasında bir ilişki olabilir. Bu çalışmanın amacı tiroid ve tiroid dışı otoimmün hastalıkların prevalansını, artmış otoimmünite, yaşam kalitesi, depresyon, ve prolaktinomalı hastalarda anksiyetedir. Yöntemler: Çalışmaya prolaktinomalı 56 premenopozal kadın ve 50 sağlıklı premenopozal kadın dahil edildi. Anti-nükleer antikor, romatoid faktör immünoglobulin M (IgM) (RF-IgM), anti-çift sarmallı DNA (anti-dsDNA), anti-transglutaminaz IgA (anti TG-IgA) ve anti-Sjogren sendromunu içeren otoimmün belirteçler A (anti-ssA), serum BAFF, APRIL ve B12 vitamini düzeyleri, tiroid fonksiyon testleri, anti-tiroid peroksidaz (anti-TPO), anti-tiroglobulin ve tiroid Doppler ultrasonu değerlendirildi. Kısa form 36, Beck Depresyon Envanteri ve Beck Anksiyete Envanteri testleri de kullanıldı. Bulgular: Hasta grubunda otoimmün tiroidit (AIT) prevalansı %32,1 iken, yeni tanı alan AIT prevalansı kontrollerle benzerdi (p>0,05). Prolaktinomalı hastalarda B12 vitamini eksikliği kontrollere göre daha yüksekti (%25,6 ve %9,1, p=0,016). Otoantikor pozitifliği gruplar arasında benzer bulundu (%35,7 ve %28,1, p=0,25). Prolaktinomalı hastalarda serum BAFF ve APRIL düzeyleri kontrollerden farklı değildi (p>0,05). AIT olan ve olmayan hastalar ile herhangi bir otoantikor pozitifliği olan ve olmayan hastalar arasında yaşam kalitesi, anksiyete ve depresyon skorları farklı değildi (p>0,05). Sonuç: Çalışmamızda hastaların üçte birine AİT tanısı konuldu ve hastaların dörtte birinde B12 vitamini eksikliği vardı. Ancak prolaktinomalı hastalarda tiroid dışı otoimmün hastalıklar artmadı ve serum BAFF/APRIL düzeylerinde değişiklik saptanmadı. [ABSTRACT FROM AUTHOR] |
|
Copyright of Gazi Medical Journal is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
