Bibliographic Details
| Title: |
International council for standardisation in haematology recommendations on fibrinogen assays, thrombin clotting time and related tests in the investigation of bleeding disorders. |
| Authors: |
Mackie, Ian1 i.mackie@ucl.ac.uk, Casini, Alessandro2, Pieters, Marlien3,4, Pruthi, Rajiv5, Reilly‐Stitt, Chris6, Suzuki, Atsuo7 |
| Source: |
International Journal of Laboratory Hematology. Feb2024, Vol. 46 Issue 1, p20-32. 13p. |
| Subject Terms: |
*HEMORRHAGE diagnosis, *PROTHROMBIN time, *PATHOLOGICAL laboratories, *HEMATOLOGY, *POINT-of-care testing, *MICROSCOPY, *GENETIC testing, *ANTICOAGULANTS, *FIBRINOGEN, *THROMBIN time, *HEPARIN |
| Abstract: |
This guidance was prepared on behalf of the International Council for Standardisation in Haematology (ICSH) by an international working group of clinicians and scientists. The document focuses on tests and assays used for the assessment of fibrinogen function, particularly in the scenario of bleeding disorders. Thrombin clotting time (TT) is used as a screening test in some laboratories and also has some utility when direct anticoagulants are in use. The Clauss fibrinogen assay remains the method of choice for the assessment of fibrinogen function, but there are some situations where the results may be misleading. Prothrombin time derived fibrinogen assays are frequently used, but should be interpreted with caution; the results are not interchangeable between different methods and fibrinogen can be overestimated in certain clinical scenarios. Viscoelastic point of care methods may be helpful in emergency situations, while Reptilase time (and similar tests) are useful combined with TT in distinguishing heparin contamination of samples (i.e., if an incorrect blood draw is suspected) and the presence of direct thrombin inhibitors. Fibrinogen antigen assays should be used in the investigation of functional fibrinogen abnormalities; fibrinogen antigen and genetic testing are recommended in the confirmation of congenital fibrinogen disorders. The following recommendations for fibrinogen function assessment are based on published literature and expert opinion and should supplement local regulations and standards. [ABSTRACT FROM AUTHOR] |
|
Copyright of International Journal of Laboratory Hematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
