| Title: |
Language deficits in primary lateral sclerosis: cortical atrophy, white matter degeneration and functional disconnection between cerebral regions. |
| Authors: |
Tan, Ee Ling1 (AUTHOR), Tahedl, Marlene1 (AUTHOR), Lope, Jasmin1 (AUTHOR), Hengeveld, Jennifer C.2 (AUTHOR), Doherty, Mark A.2 (AUTHOR), McLaughlin, Russell L.2 (AUTHOR), Hardiman, Orla1 (AUTHOR), Chang, Kai Ming1 (AUTHOR), Finegan, Eoin1 (AUTHOR), Bede, Peter1,3 (AUTHOR) bedep@tcd.ie |
| Source: |
Journal of Neurology. Jan2024, Vol. 271 Issue 1, p431-445. 15p. |
| Subject Terms: |
*AMYOTROPHIC lateral sclerosis, *WHITE matter (Nerve tissue), *CEREBRAL atrophy, *PREFRONTAL cortex, *NATIVE language, *NEUROLINGUISTICS |
| Abstract: |
Background: Primary lateral sclerosis (PLS) is traditionally regarded as a pure upper motor neuron disorder, but recent cases series have highlighted cognitive deficits in executive and language domains. Methods: A single-centre, prospective neuroimaging study was conducted with comprehensive clinical and genetic profiling. The structural and functional integrity of language-associated brain regions and networks were systematically evaluated in 40 patients with PLS in comparison to 111 healthy controls. The structural integrity of the arcuate fascicle, frontal aslant tract, inferior occipito-frontal fascicle, inferior longitudinal fascicle, superior longitudinal fascicle and uncinate fascicle was evaluated. Functional connectivity between the supplementary motor region and the inferior frontal gyrus and connectivity between Wernicke's and Broca's areas was also assessed. Results: Cortical thickness reductions were observed in both Wernicke's and Broca's areas. Fractional anisotropy reduction was noted in the aslant tract and increased radical diffusivity (RD) identified in the aslant tract, arcuate fascicle and superior longitudinal fascicle in the left hemisphere. Functional connectivity was reduced along the aslant track, i.e. between the supplementary motor region and the inferior frontal gyrus, but unaffected between Wernicke's and Broca's areas. Cortical thickness alterations, structural and functional connectivity changes were also noted in the right hemisphere. Conclusions: Disease-burden in PLS is not confined to motor regions, but there is also a marked involvement of language-associated tracts, networks and cortical regions. Given the considerably longer survival in PLS compared to ALS, the impact of language impairment on the management of PLS needs to be carefully considered. [ABSTRACT FROM AUTHOR] |
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