Bibliographic Details
| Title: |
Blood collection in heparin vs. EDTA results in an inflammasome-independent increase in monocyte distribution width at 4 h. |
| Authors: |
Eisinger, Gregory J.1 (AUTHOR) Gregory.Eisinger@osumc.edu, Osman, Wissam2 (AUTHOR), Prather, Evan R.2 (AUTHOR), Julian, Mark W.2 (AUTHOR), Gavrilin, Mikhail A.3 (AUTHOR), Crouser, Elliott D.3 (AUTHOR), Wewers, Mark D.3 (AUTHOR) |
| Source: |
Clinical Chemistry & Laboratory Medicine. Jan2024, Vol. 62 Issue 2, pe26-e28. 3p. |
| Subject Terms: |
*BLOOD collection, *ETHYLENEDIAMINETETRAACETIC acid, *HEPARIN, *SEPSIS, *BLOOD sampling, *INFLAMMASOMES |
| Abstract: |
This letter discusses the impact of different anticoagulants on monocyte distribution width (MDW), a biomarker for sepsis. The study found that blood samples collected in heparin sodium (HS) tubes had higher MDW values compared to samples collected in ethylenediaminetetraacetic acid (EDTA) tubes after a 4-hour incubation. The increase in MDW in HS samples was not associated with inflammasome activation, suggesting that other factors such as osmotic properties or cell clumping may be responsible. The findings raise questions about the use of heparin in sepsis screening and highlight the need for further research. [Extracted from the article] |
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| Database: |
Academic Search Complete |
