Bibliographic Details
| Title: |
Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers. |
| Authors: |
Xie, Chuanbo1 (AUTHOR) xiechb@sysucc.org.cn, Wang, Shuqing1 (AUTHOR), Guo, Chi2 (AUTHOR), Liu, Yuying1 (AUTHOR), Zeng, Musheng3,4 (AUTHOR) zengmsh@sysucc.org.cn |
| Source: |
Cellular Oncology (2211-3428). Dec2023, Vol. 46 Issue 6, p1725-1729. 5p. |
| Subject Terms: |
*LUNG diseases, *LUNG cancer, *MACROPHAGES, *PULMONARY nodules, *EARLY detection of cancer, *LUNGS |
| Abstract: |
The detection of biomarkers in blood macrophages is a new non-invasive cancer screening method, but its performance in early stage lung cancer screening remains undetermined. We evaluated the Apo10 and TKTL1 levels in blood macrophages of 156 early-stage lung cancer patients and 153 controls. APT (combination of Apo10 and TKTL1) level was significantly higher in the lung cancer group than that in the control group (P < 0.001). AUROC analysis showed that APT has high diagnostic value in differentiating early-stage lung cancer (AUC = 0.9132) and can be considered a biomarker for screening lung cancer patients from individuals with lung nodules. [ABSTRACT FROM AUTHOR] |
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