| Title: |
A high urinary urobilinogen/serum total bilirubin ratio indicates acute hepatic porphyria in patients with abdominal pain. |
| Authors: |
Song, Chengyuan1 (AUTHOR), Liu, Yuan2,3 (AUTHOR) liuyuan@qiluhospital.com |
| Source: |
Scientific Reports. 12/5/2023, Vol. 13 Issue 1, p1-7. 7p. |
| Subject Terms: |
*ABDOMINAL pain, *BILIRUBIN, *PORPHYRIA, *RECEIVER operating characteristic curves, *REFERENCE values |
| Abstract: |
Acute hepatic porphyria (AHP) has always been a diagnostic dilemma for physicians due to its variable symptoms. Correct diagnosis mainly depends on the detection of an elevated urinary porphobilinogen (PBG), which is not a routine test and highly relies on the physician's awareness of AHP. In the present study, we identified a more convenient indicator during routine examinations to improve the diagnosis of AHP. We found that AHP patients showed a significant higher "FALSE" urinary urobilinogen level caused by urinary PBG during the urinalysis when detected by strips impregnated with Ehrlich reagent (P < 0.05). And a remarkable increase in the urinary urobilinogen/serum total bilirubin ratio was observed in AHP patients. The area under the ROC curve of this ratio for AHP was 1.000 (95% confidence interval 1.000–1.000, P < 0.01). A cutoff value of 3.22 for this ratio yielded a sensitivity of 100% and a specificity of 100% to distinguish AHP patients from the controls. Thus, we proved that a "falsely" high urinary urobilinogen level that was adjusted by the serum total bilirubin level (urinary urobilinogen/serum total bilirubin ratio) could be used as a sensitive and specific screening marker for AHP in patients with abdominal pain. [ABSTRACT FROM AUTHOR] |
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