| Title: |
Alzheimer's Disease CSF Biomarkers as Possible Indicators of Tap-Test Response in Idiopathic Normal Pressure Hydrocephalus. |
| Authors: |
Pyrgelis, Efstratios-Stylianos1,2 (AUTHOR) geoprskvs44@gmail.com, Paraskevas, George P.2,3 (AUTHOR) fboufidou@med.uoa.gr, Constantinides, Vasilios C.1,2 (AUTHOR) myrtop@yahoo.com, Boufidou, Fotini2 (AUTHOR), Papaioannou, Myrto2 (AUTHOR), Stefanis, Leonidas1 (AUTHOR) lstefanis@med.uoa.gr, Kapaki, Elisabeth1,2 (AUTHOR) ekapaki@med.uoa.gr |
| Source: |
Brain Sciences (2076-3425). Nov2023, Vol. 13 Issue 11, p1593. 11p. |
| Subject Terms: |
*ALZHEIMER'S disease, *TAU proteins, *HYDROCEPHALUS, *MINI-Mental State Examination, *NEUROPSYCHOLOGICAL tests |
| Abstract: |
The aim of the present study is the evaluation of established Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers in patients with idiopathic normal-pressure hydrocephalus (iNPH), both individually and as a total profile, and the investigation of their use as potential predictors of Tap-test responsiveness. Fifty-three patients with iNPH participated in the study. Aβ42, Aβ40, total Tau and phospho-Tau proteins were measured in duplicate with double-sandwich ELISA assays. Clinical evaluation involved a 10 m timed walk test before an evacuative lumbar puncture (LP) and every 24 h for three consecutive days afterwards. Neuropsychological assessment involved a mini-mental state examination, frontal assessment battery, 5-word test and CLOX drawing test 1 and 2, which were also performed before and 48 h after LP. Response in the Tap-test was defined as a 20% improvement in gait and/or a 10% improvement in neuropsychological tests. The Aβ42/Aβ40 ratio was found to be significantly higher in Tap-test responders than non-responders. Total Tau and phospho-Tau CSF levels also differed significantly between these two groups, with Tap-test responders presenting with lower levels compared to non-responders. Regarding the AD CSF biomarker profile (decreased amyloid and increased Tau proteins levels), patients with a non-AD profile were more likely to have a positive response in the Tap-test than patients with an AD profile. [ABSTRACT FROM AUTHOR] |
|
Copyright of Brain Sciences (2076-3425) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
