| Title: |
Incidence of acute haemolytic transfusion reaction among ABO‐incompatible recipients transfused with A3 blood: A case series. |
| Authors: |
Latour, Catherine1 (AUTHOR) catherine.latour@hema-quebec.qc.ca, Gaussen, Amaury2 (AUTHOR), Beaudoin, Julie3 (AUTHOR), Leiva‐Torres, Gabriel André1 (AUTHOR), Rochette, Samuel4 (AUTHOR), Robitaille, Nancy1 (AUTHOR) |
| Source: |
Vox Sanguinis. Oct2023, Vol. 118 Issue 10, p854-862. 9p. 1 Diagram, 4 Charts. |
| Subject Terms: |
*BLOOD transfusion reaction, *BLOOD group incompatibility, *RED blood cell transfusion, *JUDGMENT (Psychology) |
| Geographic Terms: |
QUEBEC (Quebec) |
| Abstract: |
Background and Objectives: ABO antigens are among the most immunogenic, but the haemolytic risks of ABO incompatibilities involving a donor with a weak ABO phenotype are little documented. Materials and Methods: This retrospective case series assessed the incidence of acute haemolytic transfusion reaction (AHTR) among ABO‐incompatible recipients of A3 blood in Québec (Canada). Transfusion safety officers reported laboratory AHTR indicators measured ≤24 h pre‐ and post‐transfusion. Because the AHTR case definition of Québec's Hemovigilance System (QHS) leaves significant room for clinical judgement, a two‐step approach was used to assess potential cases: Step 1 consisted in a highly sensitive—but unspecific—initial screen that identified all candidate cases per QHS case definition, and Step 2 consisted in a detailed review of candidate cases by two haematologists. Results: Nine donors initially typed as Group B (N = 1) or O (N = 8) were subsequently found to display an A3B or A3O phenotype. Eighty‐one recipients received ABO‐incompatible blood, including 53 (65.4%) with interpretable data. Of these, 29 (54.7%) were classified as candidate cases after Step 1. Following Step 2, no conclusive evidence of AHTR was found: Abnormal pre‐ versus post‐transfusion changes appeared modest, within normal range, insufficient to ascertain AHTR, or were consistent with a pre‐existing condition unrelated to AHTR. Two candidate cases had a QHS‐reported transfusion reaction; both were unrelated to AHTR. Conclusion: In this case series, no conclusive evidence of serious AHTR was found among ABO‐incompatible recipients who were inadvertently transfused with A3 blood. [ABSTRACT FROM AUTHOR] |
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