Bibliographic Details
| Title: |
Synthesis, Crystal Structure and Anti-Leukemic Activity of (E)-Pyrrolo[1,2- a ]quinoxalin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one. |
| Authors: |
Guillon, Jean1 (AUTHOR) jean.guillon@u-bordeaux.fr, Savrimoutou, Solène1 (AUTHOR) sandra.rubio@u-bordeaux.fr, Albenque-Rubio, Sandra1 (AUTHOR) nina.fillova@etu.u-bordeaux.fr, Pinaud, Noël2 (AUTHOR) noel.pinaud@u-bordeaux.fr, Fillová, Nina1 (AUTHOR) stephane.moreau@u-bordeaux.fr, Moreau, Stéphane1 (AUTHOR), Baylot, Virginie3 (AUTHOR) virginie.baylot@inserm.fr, Desplat, Vanessa4 (AUTHOR) vanessa.desplat@u-bordeaux.fr |
| Source: |
Molbank. Sep2023, Vol. 2023 Issue 3, pM1691. 7p. |
| Subject Terms: |
*CRYSTAL structure, *QUINOXALINE compounds, *CELL lines, *LEUKEMIA |
| Abstract: |
(E)-Pyrrolo[1,2-a]quinoxalin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one was designed then synthesized using a multi-step pathway starting from commercially available 2-nitroaniline. Structure characterization of this original substituted pyrrolo[1,2-a]quinoxaline compound was achieved by using FT-IR, 1H-NMR, 13C-NMR, X-Ray and HRMS spectral analysis. This new pyrroloquinoxaline shows interesting cytotoxic potential against different human leukemia cell lines (MV4-11, K562, MOLM14 and Jurkat cells). [ABSTRACT FROM AUTHOR] |
|
Copyright of Molbank is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
