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DARESOME enables concurrent profiling of multiple DNA modifications with restriction enzymes in single cells and cell-free DNA.

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Title: DARESOME enables concurrent profiling of multiple DNA modifications with restriction enzymes in single cells and cell-free DNA.
Authors: Viswanathan, Ramya1,2, Cheruba, Elsie1,2, Pui-Mun Wong3, Yao Yi4, Shaun Ngang1,2, Dawn Qingqing Chong5,6, Yuin-Han Loh4,7, Tan, Iain Beehuat3,5,6, Lih Feng Cheow1,2 lihfeng.cheow@nus.edu.sg
Source: Science Advances. 9/13/2023, Vol. 9 Issue 37, p1-14. 14p.
Abstract: The article discusses DNA modifications, specifically 5-methylcytosines (5mCs) and 5-hydroxymethylcytosine (5hmC), which play crucial roles in gene regulation and epigenetics. It highlights the challenges in distinguishing between these modifications in DNA sequencing and explores various methods, including restriction enzyme-based assays, for accurate measurement and profiling of these modifications, allowing for a better understanding of their roles in cellular functions.
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  Data: DARESOME enables concurrent profiling of multiple DNA modifications with restriction enzymes in single cells and cell-free DNA.
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  Data: <searchLink fieldCode="AR" term="%22Viswanathan%2C+Ramya%22">Viswanathan, Ramya</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Cheruba%2C+Elsie%22">Cheruba, Elsie</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Pui-Mun+Wong%22">Pui-Mun Wong</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Yao+Yi%22">Yao Yi</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Shaun+Ngang%22">Shaun Ngang</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Dawn+Qingqing+Chong%22">Dawn Qingqing Chong</searchLink><relatesTo>5,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Yuin-Han+Loh%22">Yuin-Han Loh</searchLink><relatesTo>4,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Tan%2C+Iain+Beehuat%22">Tan, Iain Beehuat</searchLink><relatesTo>3,5,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Lih+Feng+Cheow%22">Lih Feng Cheow</searchLink><relatesTo>1,2</relatesTo><i> lihfeng.cheow@nus.edu.sg</i>
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  Data: <searchLink fieldCode="JN" term="%22Science+Advances%22">Science Advances</searchLink>. 9/13/2023, Vol. 9 Issue 37, p1-14. 14p.
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  Label: Abstract
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  Data: The article discusses DNA modifications, specifically 5-methylcytosines (5mCs) and 5-hydroxymethylcytosine (5hmC), which play crucial roles in gene regulation and epigenetics. It highlights the challenges in distinguishing between these modifications in DNA sequencing and explores various methods, including restriction enzyme-based assays, for accurate measurement and profiling of these modifications, allowing for a better understanding of their roles in cellular functions.
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        Value: 10.1126/sciadv.adi0197
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        Text: English
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            NameFull: Cheruba, Elsie
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            NameFull: Pui-Mun Wong
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              M: 09
              Text: 9/13/2023
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              Y: 2023
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              Value: 37
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