Bibliographic Details
| Title: |
Association between Human Leukocyte Antigen and End-Stage Renal Disease in Patients from Transylvania, Romania. |
| Authors: |
Iancu Loga, Luminita-Ioana1,2 (AUTHOR) ioan.elec@gmail.com, Dican, Lucia2,3 (AUTHOR) ccatana0128@gmail.com, Chiorean, Alin Dan1 (AUTHOR) chiorean_alin_dan@yahoo.com, Chelaru, Vlad Florin4 (AUTHOR) vladflorinchelaru@gmail.com, Elec, Florin Ioan2,5 (AUTHOR), Catana, Cristina Sorina3 (AUTHOR), Marta, Monica Mihaela4 (AUTHOR) mmarta@umfcluj.ro, Lucaciu, Roxana Liana6 (AUTHOR) roxanaluc@yahoo.com, Hangan, Adriana Corina7 (AUTHOR) acomsa6@yahoo.com, Bondor, Cosmina Ioana8 (AUTHOR) cbondor@umfcluj.ro, Vica, Mihaela Laura1 (AUTHOR) mvica@umfcluj.ro, Matei, Horea Vladi1 (AUTHOR) hmatei@umfcluj.ro |
| Source: |
International Journal of Molecular Sciences. Sep2023, Vol. 24 Issue 17, p13383. 13p. |
| Subject Terms: |
*HLA histocompatibility antigens, *CHRONIC kidney failure, *ALLELES, *LOGISTIC regression analysis, *HAPLOTYPES, *KIDNEY transplantation |
| Geographic Terms: |
TRANSYLVANIA (Romania), ROMANIA |
| Abstract: |
End-stage renal disease (ESRD) is the final stage of chronic kidney disease. This study explored the association between human leukocyte antigen (HLA) and ESRD. The interaction between genetic and environmental factors may also play a role in the development of ESRD. The study included 2392 ESRD patients who were awaiting renal transplantation. Blood samples were genotyped by SSOP and SSP-PCR methods. Multivariate logistic regression analysis showed that HLA-A*11 (p = 0.027), HLA-A*34 (p = 0.017), HLA-A*69 (p = 0.012), HLA-B*41 (p < 0.001), HLA-B*50 (p = 0.004), HLA-DRB1*10 (p = 0.027), and HLA-DRB1*14 (p = 0.004) were positively associated with ESRD (OR > 1); HLA-DRB1*07 (p < 0.001), HLA-DRB1*08 (p = 0.005), and HLA-DRB1*13 (p < 0.001) were protective against ESRD (OR < 1); and the three-locus haplotype HLA-A*02–B*41–DRB1*03, containing one susceptible allele, was strongly associated with ESRD (p < 0.001, OR = 3.15). In conclusion, this retrospective analysis of HLA typing in patients with ESRD of various etiologies suggests that molecular data on the HLA polymorphism should be collected in order to identify high-risk ESRD patients and to improve graft survival after kidney transplantation. [ABSTRACT FROM AUTHOR] |
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