Bibliographic Details
| Title: |
Advances in Mitochondria-Targeted Drug Delivery. |
| Authors: |
Bottani, Emanuela1 (AUTHOR) emanuela.bottani@univr.it, Brunetti, Dario2,3 (AUTHOR) emanuela.bottani@univr.it |
| Source: |
Pharmaceutics. Aug2023, Vol. 15 Issue 8, p2089. 5p. |
| Subject Terms: |
*CALCIUM-dependent potassium channels, *RECESSIVE genes, *MITOCHONDRIA, *SARCOPENIA, *FRIEDREICH'S ataxia, *ADRENOLEUKODYSTROPHY, *PARKIN (Protein), *PPAR-gamma agonists |
| Abstract: |
Khan et al. discussed the recent advancements in mitochondria-targeted drug delivery strategies, including small lipophilic cationic molecules, mitochondria-targeting signal peptides, penetrating peptides, and nanoparticle-based drug delivery, as well as their challenges and limitations [[17]]. Mitochondrial dysfunctions - e.g., alterations of mitochondrial biogenesis, mitochondrial fusion-fission imbalance, mitochondrial-damage-associated molecular patterns, and oxidative stress, among others - have recently been linked to the pathophysiologies of various forms of kidney diseases and potentially provide alternative approaches to their treatments. Additionally, they discussed the existing treatments that aim to intervene in these pathways and contemplate potential future directions for anti-ageing and anti-senescence therapies focusing on mitochondria [[22]]. The identification of mitochondria as an emerging pharmaceutical target has led to the development of several mitochondrial targeting strategies for the treatment of these diseases. [Extracted from the article] |
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