Bibliographic Details
| Title: |
Feasibility and safety of non-contrast optical coherence tomography imaging using hydroxyethyl starch in coronary arteries. |
| Authors: |
Kang, Dong Oh1,2 (AUTHOR), Nam, Hyeong Soo3 (AUTHOR), Kim, Sunwon1,4 (AUTHOR), Yoo, Hongki3 (AUTHOR) h.yoo@kaist.ac.kr, Kim, Jin Won1,2 (AUTHOR) kjwmm@korea.ac.kr |
| Source: |
Scientific Reports. 8/24/2023, Vol. 13 Issue 1, p1-12. 12p. |
| Subject Terms: |
*HYDROXYETHYL starch, *CORONARY arteries, *OPTICAL coherence tomography, *INTRAVASCULAR ultrasonography, *STARCH, *KIDNEY diseases, *ALTERNATIVE mass media |
| Abstract: |
Intracoronary optical coherence tomography (OCT) requires injection of flushing media for image acquisition. Alternative flushing media needs to be investigated to reduce the risk of contrast-induced renal dysfunction. We investigated the feasibility and safety of pentastarch (hydroxyethyl starch) for clinical OCT imaging. We prospectively enrolled 43 patients with 70 coronary lesions (46-stented; 24-native). Total 81 OCT pullback pairs were obtained by manual injection of iodine contrast, followed by pentastarch. Each pullback was assessed frame-by-frame using an automated customized lumen contour/stent strut segmentation algorithm. Paired images were compared for the clear image segments (CIS), blood-flushing capability, and quantitative morphometric measurements. Overall image quality, as assessed by the proportion of CIS, was comparable between the contrast- and pentastarch-flushed images (97.1% vs. 96.5%; p = 0.160). The pixel-based blood-flushing capability was similar between the groups (0.951 [0.947–0.953] vs. 0.950 [0.948–0.952], p = 0.125). Quantitative two- and three-dimensional morphometric measurements of the paired images correlated well (p < 0.001) with excellent inter-measurement variability. All patients safely underwent OCT imaging using pentastarch without resulting in clinically relevant complications or renal deterioration. Non-contrast OCT imaging using pentastarch is clinically safe and technically feasible with excellent image quality and could be a promising alternative strategy for patients at high risk of renal impairment. [ABSTRACT FROM AUTHOR] |
|
Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
