| Title: |
Imiquimod chemoprophylaxis for field cancerization in xeroderma pigmentosum patients—A prospective study. |
| Authors: |
Rocha, Lílian Kelly Faria Licarião1 (AUTHOR) lilianrocha@me.com, Ferreira, Paula2 (AUTHOR), Gianotti, Marcelo A.2 (AUTHOR), Avancini, João2 (AUTHOR), Menck, Carlos F. M.3 (AUTHOR), Castro, Ligia P.3 (AUTHOR), de Oliveira, Zilda Najjar Prado2 (AUTHOR), Rivitti, Maria C.2 (AUTHOR), Samorano, Luciana P.2 (AUTHOR), Pereira, Naiura Vieira4 (AUTHOR), Festa Neto, Cyro1 (AUTHOR) |
| Source: |
Australasian Journal of Dermatology. Aug2023, Vol. 64 Issue 3, p435-438. 4p. 2 Color Photographs, 1 Diagram. |
| Subject Terms: |
*XERODERMA pigmentosum, *IMIQUIMOD, *CHEMOPREVENTION, *IMMUNOMODULATORS, *SKIN cancer, *LONGITUDINAL method, *SUNBURN |
| Abstract: |
We strongly recommend preventive approaches for XP patients to minimize the number of necessary excisions and the incidence of tumours and facilitate the early recognition of cutaneous tumours in this population. Xeroderma pigmentosum (XP) is a rare genetic disorder that precipitates field cancerization in sun-exposed areas, causing abnormalities that can progress to skin cancers.[1] Sun protection is the chief intervention strategy for XP patients, but this approach is often insufficient. We have proposed a chemoprophylaxis protocol with topical imiquimod for XP patients, noting RCM and histological benefits of this strategy, with no serious adverse events. [Extracted from the article] |
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