Bibliographic Details
Title: |
Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19. |
Authors: |
Davidson, Bruce L.1 (AUTHOR) brucedavidson@pobox.com, Levi, Marcel M.2,3 (AUTHOR) |
Source: |
JAMA: Journal of the American Medical Association. 8/1/2023, Vol. 330 Issue 5, p471-472. 2p. |
Subject Terms: |
*COVID-19, *HEPARIN |
Abstract: |
Comment & Response B To the Editor b A recent study[1] of treatment effects of therapeutic-dose heparin in patients hospitalized for COVID-19 analyzed patients on the ward (treatment-dose heparin was efficacious) separately from critically ill patients (treatment-dose heparin was not efficacious). The authors described this trial design as "fortuitous."[1] However, we are concerned that the no-difference result in critically ill patients may have occurred because subcutaneous depot dosing of low-molecular-weight heparin (LMWH) has poor systemic exposure in critically ill patients, particularly in those receiving vasopressors. [Extracted from the article] |
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Database: |
Academic Search Complete |