Bibliographic Details
| Title: |
The Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer. |
| Authors: |
Montecillo-Aguado, Mayra1,2 (AUTHOR) mayramontecillo@gmail.com, Tirado-Rodriguez, Belen1 (AUTHOR) abtirado81@gmail.com, Huerta-Yepez, Sara1 (AUTHOR) shuertay@gmail.com |
| Source: |
International Journal of Molecular Sciences. Jul2023, Vol. 24 Issue 14, p11691. 24p. |
| Subject Terms: |
*UNSATURATED fatty acids, *ESSENTIAL fatty acids, *OMEGA-6 fatty acids, *OMEGA-3 fatty acids, *LINOLEIC acid, *ARACHIDONIC acid, *EICOSAPENTAENOIC acid |
| Abstract: |
Cancer is a significant global public health issue and, despite advancements in detection and treatment, the prognosis remains poor. Cancer is a complex disease characterized by various hallmarks, including dysregulation in apoptotic cell death pathways. Apoptosis is a programmed cell death process that efficiently eliminates damaged cells. Several studies have indicated the involvement of polyunsaturated fatty acids (PUFAs) in apoptosis, including omega-3 PUFAs such as alpha-linolenic acid, docosahexaenoic acid, and eicosapentaenoic acid. However, the role of omega-6 PUFAs, such as linoleic acid, gamma-linolenic acid, and arachidonic acid, in apoptosis is controversial, with some studies supporting their activation of apoptosis and others suggesting inhibition. These PUFAs are essential fatty acids, and Western populations today have a high consumption rate of omega-6 to omega-3 PUFAs. This review focuses on presenting the diverse molecular mechanisms evidence in both in vitro and in vivo models, to help clarify the controversial involvement of omega-3 and omega-6 PUFAs in apoptosis mechanisms in cancer. [ABSTRACT FROM AUTHOR] |
|
Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
