| Title: |
Assisted Reproductive Technology and Perinatal Mortality: Selected States (2006–2011). |
| Authors: |
Chang, Jeani1 jeanijychang@gmail.com, Zhang, Yujia1, Boulet, Sheree L.2, Crawford, Sara B.1, Copeland, Glenn E.3, Bernson, Dana4, Kirby, Russell S.5, Kissin, Dmitry M.1, Barfield, Wanda D.1 |
| Source: |
American Journal of Perinatology. 2023, Vol. 40 Issue 9, p953-959. 7p. |
| Subject Terms: |
*MASSAGE therapy, *CONFIDENCE intervals, *RETROSPECTIVE studies, *COMPARATIVE studies, *PERINATAL death, *INFANT death, *HUMAN reproductive technology, *RESEARCH funding, *INFANT mortality, *ODDS ratio, *LONGITUDINAL method |
| Geographic Terms: |
FLORIDA, MICHIGAN |
| Abstract: |
Objective This study aimed to compare trends and characteristics of assisted reproductive technology (ART) and non-ART perinatal deaths and to evaluate the association of perinatal mortality and method of conception (ART vs. non-ART) among ART and non-ART deliveries in Florida, Massachusetts, and Michigan from 2006 to 2011. Study Design Retrospective cohort study using linked ART surveillance and vital records data from Florida, Massachusetts, and Michigan. Results During 2006 to 2011, a total of 570 ART-conceived perinatal deaths and 25,158 non-ART conceived perinatal deaths were identified from the participating states. Overall, ART perinatal mortality rates were lower than non-ART perinatal mortality rates for both singletons (7.0/1,000 births vs. 10.2/1,000 births) and multiples (22.8/1,000 births vs. 41.2/1,000 births). At <28 weeks of gestation, the risk of perinatal death among ART singletons was significantly lower than non-ART singletons (adjusted risk ratio [aRR] = 0.46, 95% confidence interval [CI]: 0.26–0.85). Similar results were observed among multiples at <28 weeks of gestation (aRR = 0.64, 95% CI: 0.45–0.89). Conclusion Our findings suggest that ART use is associated with a decreased risk of perinatal deaths prior to 28 weeks of gestation, which may be explained by earlier detection and management of fetal and maternal conditions among ART-conceived pregnancies. These findings provide valuable information for health care providers, including infertility specialists, obstetricians, and pediatricians when counseling ART users on risk of treatment. Key Points ART use is associated with a decreased risk of perinatal deaths prior to 28 weeks of gestation. ART perinatal mortality rates were lower than that for non-ART perinatal mortality. This study used linked data to examine associations between use of ART and perinatal deaths. [ABSTRACT FROM AUTHOR] |
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| Database: |
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