Bibliographic Details
| Title: |
Alveolar macrophages from EVALI patients and e-cigarette users: a story of shifting phenotype. |
| Authors: |
Warren, Kristi J.1,2 (AUTHOR) kristi.warren@hsc.utah.edu, Beck, Emily M.1,2 (AUTHOR), Callahan, Sean J.1,2 (AUTHOR), Helms, My N.1 (AUTHOR), Middleton, Elizabeth1 (AUTHOR), Maddock, Sean2,3 (AUTHOR), Carr, Jason R.1,4 (AUTHOR), Harris, Dixie4 (AUTHOR), Blagev, Denitza P.4 (AUTHOR), Lanspa, Michael J.4 (AUTHOR), Brown, Samuel M.4 (AUTHOR), Paine III, Robert1,2 (AUTHOR) |
| Source: |
Respiratory Research. 6/17/2023, Vol. 24 Issue 1, p1-10. 10p. |
| Subject Terms: |
*ALVEOLAR macrophages, *E-cigarette or vaping product use-associated lung injuries, *ELECTRONIC cigarettes, *CELL populations, *PHENOTYPES, *LIPID metabolism |
| Abstract: |
Exposure to e-cigarette vapors alters important biologic processes including phagocytosis, lipid metabolism, and cytokine activity in the airways and alveolar spaces. Little is known about the biologic mechanisms underpinning the conversion to e-cigarette, or vaping, product use-associated lung injury (EVALI) from normal e-cigarette use in otherwise healthy individuals. We compared cell populations and inflammatory immune populations from bronchoalveolar lavage fluid in individuals with EVALI to e-cigarette users without respiratory disease and healthy controls and found that e-cigarette users with EVALI demonstrate a neutrophilic inflammation with alveolar macrophages skewed towards inflammatory (M1) phenotype and cytokine profile. Comparatively, e-cigarette users without EVALI demonstrate lower inflammatory cytokine production and express features associated with a reparative (M2) phenotype. These data indicate macrophage-specific changes are occurring in e-cigarette users who develop EVALI. [ABSTRACT FROM AUTHOR] |
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