Objective perimetry identifies regional functional progression and recovery in mild Diabetic Macular Oedema.
| Title: | Objective perimetry identifies regional functional progression and recovery in mild Diabetic Macular Oedema. |
|---|---|
| Authors: | Sabeti, Faran1,2 (AUTHOR) faran.sabeti@anu.edu.au, Rai, Bhim B.1 (AUTHOR), van Kleef, Josh P.1 (AUTHOR), Rohan, Emilie M. F.1 (AUTHOR), Carle, Corinne F.1 (AUTHOR), Barry, Richard C.3,4 (AUTHOR), Essex, Rohan W.3,5 (AUTHOR), Nolan, Christopher J.3,5 (AUTHOR), Maddess, Ted1 (AUTHOR) |
| Source: | PLoS ONE. 6/15/2023, Vol. 18 Issue 6, p1-20. 20p. |
| Subject Terms: | *PERIMETRY, *MACULAR edema, *VISUAL fields, *TYPE 2 diabetes, *OPTICAL coherence tomography, *DIABETIC retinopathy |
| Company/Entity: | UNITED States. Food & Drug Administration |
| Abstract: | Purpose: Retinal function beyond foveal vision is not routinely examined in the clinical screening and management of diabetic retinopathy although growing evidence suggests it may precede structural changes. In this study we compare optical coherence tomography (OCT) based macular structure with function measured objectively with the ObjectiveFIELD Analyzer (OFA), and with Matrix perimetry. We did that longitudinally in Type 2 diabetes (T2D) patients with mild Diabetic Macular Oedema (DMO) with good vision and a similar number of T2D patients without DMO, to evaluate changes in retinal function more peripherally over the natural course of retinopathy. Methods: Both eyes of 16 T2D patients (65.0 ± 10.1, 10 females), 10 with baseline DMO, were followed for up longitudinally for 27 months providing 94 data sets. Vasculopathy was assessed by fundus photography. Retinopathy was graded using to Early Treatment of Diabetic Retinopathy Study (ETDRS) guidelines. Posterior-pole OCT quantified a 64-region/eye thickness grid. Retinal function was measured with 10–2 Matrix perimetry, and the FDA-cleared OFA. Two multifocal pupillographic objective perimetry (mfPOP) variants presented 44 stimuli/eye within either the central 30° or 60° of the visual field, providing sensitivities and delays for each test-region. OCT, Matrix and 30° OFA data were mapped to a common 44 region/eye grid allowing change over time to be compared at the same retinal regions. Results: In eyes that presented with DMO at baseline, mean retinal thickness reduced from 237 ± 25 μm to 234.2 ± 26.7 μm, while the initially non-DMO eyes significantly increased their mean thickness from 250.7 ± 24.4 μm to 255.7 ± 20.6 μm (both p<0.05). Eyes that reduced in retinal thickness over time recovered to more normal OFA sensitivities and delays (all p<0.021). Matrix perimetry quantified fewer regions that changed significantly over the 27 months, mostly presenting in the central 8 degrees. Conclusions: Changes in retinal function measured by OFA possibly offer greater power to monitor DMO over time than Matrix perimetry data. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Objective perimetry identifies regional functional progression and recovery in mild Diabetic Macular Oedema. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sabeti%2C+Faran%22">Sabeti, Faran</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> faran.sabeti@anu.edu.au</i><br /><searchLink fieldCode="AR" term="%22Rai%2C+Bhim+B%2E%22">Rai, Bhim B.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+Kleef%2C+Josh+P%2E%22">van Kleef, Josh P.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rohan%2C+Emilie+M%2E+F%2E%22">Rohan, Emilie M. F.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carle%2C+Corinne+F%2E%22">Carle, Corinne F.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barry%2C+Richard+C%2E%22">Barry, Richard C.</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Essex%2C+Rohan+W%2E%22">Essex, Rohan W.</searchLink><relatesTo>3,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nolan%2C+Christopher+J%2E%22">Nolan, Christopher J.</searchLink><relatesTo>3,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maddess%2C+Ted%22">Maddess, Ted</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22PLoS+ONE%22">PLoS ONE</searchLink>. 6/15/2023, Vol. 18 Issue 6, p1-20. 20p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22PERIMETRY%22">PERIMETRY</searchLink><br />*<searchLink fieldCode="DE" term="%22MACULAR+edema%22">MACULAR edema</searchLink><br />*<searchLink fieldCode="DE" term="%22VISUAL+fields%22">VISUAL fields</searchLink><br />*<searchLink fieldCode="DE" term="%22TYPE+2+diabetes%22">TYPE 2 diabetes</searchLink><br />*<searchLink fieldCode="DE" term="%22OPTICAL+coherence+tomography%22">OPTICAL coherence tomography</searchLink><br />*<searchLink fieldCode="DE" term="%22DIABETIC+retinopathy%22">DIABETIC retinopathy</searchLink> – Name: SubjectCompany Label: Company/Entity Group: Su Data: <searchLink fieldCode="DE" term="%22UNITED+States%2E+Food+%26+Drug+Administration%22">UNITED States. Food & Drug Administration</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Retinal function beyond foveal vision is not routinely examined in the clinical screening and management of diabetic retinopathy although growing evidence suggests it may precede structural changes. In this study we compare optical coherence tomography (OCT) based macular structure with function measured objectively with the ObjectiveFIELD Analyzer (OFA), and with Matrix perimetry. We did that longitudinally in Type 2 diabetes (T2D) patients with mild Diabetic Macular Oedema (DMO) with good vision and a similar number of T2D patients without DMO, to evaluate changes in retinal function more peripherally over the natural course of retinopathy. Methods: Both eyes of 16 T2D patients (65.0 ± 10.1, 10 females), 10 with baseline DMO, were followed for up longitudinally for 27 months providing 94 data sets. Vasculopathy was assessed by fundus photography. Retinopathy was graded using to Early Treatment of Diabetic Retinopathy Study (ETDRS) guidelines. Posterior-pole OCT quantified a 64-region/eye thickness grid. Retinal function was measured with 10–2 Matrix perimetry, and the FDA-cleared OFA. Two multifocal pupillographic objective perimetry (mfPOP) variants presented 44 stimuli/eye within either the central 30° or 60° of the visual field, providing sensitivities and delays for each test-region. OCT, Matrix and 30° OFA data were mapped to a common 44 region/eye grid allowing change over time to be compared at the same retinal regions. Results: In eyes that presented with DMO at baseline, mean retinal thickness reduced from 237 ± 25 μm to 234.2 ± 26.7 μm, while the initially non-DMO eyes significantly increased their mean thickness from 250.7 ± 24.4 μm to 255.7 ± 20.6 μm (both p<0.05). Eyes that reduced in retinal thickness over time recovered to more normal OFA sensitivities and delays (all p<0.021). Matrix perimetry quantified fewer regions that changed significantly over the 27 months, mostly presenting in the central 8 degrees. Conclusions: Changes in retinal function measured by OFA possibly offer greater power to monitor DMO over time than Matrix perimetry data. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1371/journal.pone.0287319 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 20 StartPage: 1 Subjects: – SubjectFull: UNITED States. Food & Drug Administration Type: general – SubjectFull: PERIMETRY Type: general – SubjectFull: MACULAR edema Type: general – SubjectFull: VISUAL fields Type: general – SubjectFull: TYPE 2 diabetes Type: general – SubjectFull: OPTICAL coherence tomography Type: general – SubjectFull: DIABETIC retinopathy Type: general Titles: – TitleFull: Objective perimetry identifies regional functional progression and recovery in mild Diabetic Macular Oedema. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sabeti, Faran – PersonEntity: Name: NameFull: Rai, Bhim B. – PersonEntity: Name: NameFull: van Kleef, Josh P. – PersonEntity: Name: NameFull: Rohan, Emilie M. F. – PersonEntity: Name: NameFull: Carle, Corinne F. – PersonEntity: Name: NameFull: Barry, Richard C. – PersonEntity: Name: NameFull: Essex, Rohan W. – PersonEntity: Name: NameFull: Nolan, Christopher J. – PersonEntity: Name: NameFull: Maddess, Ted IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 06 Text: 6/15/2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 19326203 Numbering: – Type: volume Value: 18 – Type: issue Value: 6 Titles: – TitleFull: PLoS ONE Type: main |
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