Bibliographic Details
| Title: |
Treatment of Congenital Afibrinogenemia in a Neonate With Critical Pulmonary Stenosis. |
| Authors: |
Parikh, Priya1, Diep, Kimvi2, Balasa, Vinod3, Lucas, Tiffany L.1 Tiffany.l.lucas@kp.org |
| Source: |
Journal of Pediatric Pharmacology & Therapeutics. 2023, Vol. 28 Issue 3, p268-271. 4p. |
| Subject Terms: |
*PULMONARY stenosis, *PREMATURE infants, *NEWBORN infants, *OLDER patients, *FIBRINOGEN |
| Abstract: |
Fibrinogen deficiencies in neonates can lead to bleeding complications. In this report, we describe a case of congenital afibrinogenemia in a newborn with critical pulmonary stenosis who presented with bilateral cephalohematomas after an uncomplicated delivery. The initial use of cryoprecipitate was followed by administration of fibrinogen concentrate. We estimated a half-life of 24 to 48 hours with the concentrate product. This patient received fibrinogen replacement and had a subsequent successful cardiac repair. The drug’s shorter half-life in this neonate contrasts with prior reports of longer half-life in older patients and is important to note in treating future neonatal patients with this diagnosis. [ABSTRACT FROM AUTHOR] |
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| Database: |
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