Bioengineered particles expand myelin-specific regulatory T cells and reverse autoreactivity in a mouse model of multiple sclerosis.

Bibliographic Details
Title:	Bioengineered particles expand myelin-specific regulatory T cells and reverse autoreactivity in a mouse model of multiple sclerosis.
Authors:	Rhodes, Kelly R.^1,2, Tzeng, Stephany Y.^1,2, Iglesias, Marcos³, Dongwoo Lee^1,2, Storm, Kaitlyn^1,2, Neshat, Sarah Y.^1,2, Van Dyke, Derek^2,4, Lowmaster, Shirley M.^1,2,3, Spangler, Jamie B.^{1,2,4,5,6,7,8}, Raimondi, Giorgio³, Green, Jordan J.^{1,2,4,5,6,7,9,10} green@jhu.edu
Source:	Science Advances. 6/2/2023, Vol. 9 Issue 22, p1-13. 13p.
Abstract:	The article focuses on a novel therapy for multiple sclerosis (MS) using bioengineered particles. Topics include the development of microparticles loaded with rapamycin and functionalized with interleukin-2 (IL-2) and major histocompatibility complex (MHC) class II to target and activate myelin-specific regulatory T cells, leading to disease reversal and potential treatment for autoimmune diseases.
Database:	Academic Search Complete