Bibliographic Details
| Title: |
Preparation and Characterization of Hydrogel Beads for Controlled Release of Amoxicillin. |
| Alternate Title: |
تحضير وتوصيف حبيبات هلامية مائية تحرِّر الأموكسيسيلين بشكل مضبوط. |
| Authors: |
Almasri, Rasha1 r.almasri@albaath-univ.edu.sy, Swed, Amin2, Alali, Haifaa1 |
| Source: |
Jordan Journal of Pharmaceutical Sciences. Dec2022, Vol. 15 Issue 4, p523-535. 13p. |
| Subject Terms: |
*SODIUM alginate, *HYDROGELS, *POLOXAMERS, *AMOXICILLIN, *DRUG delivery systems, *CALCIUM chloride |
| Abstract: |
Amoxicillin trihydrate-loaded hydrogel beads were prepared and characterized as a controlled drug delivery system to improve patient compliance. An ionotropic gelation process was used to prepare the hydrogel beads using calcium chloride (CaCl2) as a crosslinking agent. The effects of CaCl2, sodium alginate, poloxamer 407 (PL) concentration, and preparation temperature were investigated. Spherical hydrogel beads were obtained with high encapsulation efficiency (85.74±1.09) %. FTIR analyses confirmed the compatibility of amoxicillin with the used excipients. In vitro swelling and cumulative drug release studies were performed over 24 hours in HCl medium, pH 1.2. Prepara-tion temperature was found to influence both the index of beads swelling (SI) and the cumulative release of amoxicil-lin. The study demonstrated the capability of PL to enhance the cumulative release of amoxicillin, correlating with swelling behavior. The proposed hydrogel beads have the potential as a promising drug delivery system for controlled release of amoxicillin, over 24 hours, and thus reduced dosing frequency. [ABSTRACT FROM AUTHOR] |
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| Database: |
Academic Search Complete |
