| Title: |
Surface-functionalized luteolin-loaded nanocarriers successfully delayed lung cancer progress in rats. |
| Authors: |
Sen, Ramkrishna1 (AUTHOR), Mukherjee, Biswajit1 (AUTHOR) biswajit.mukherjee@jadavpuruniversity.in, Ganguly, Soumya2 (AUTHOR), Sinha, Samarendu3 (AUTHOR) |
| Source: |
Journal of Materials Science. May2023, Vol. 58 Issue 18, p7731-7757. 27p. 1 Color Photograph, 1 Diagram, 4 Graphs. |
| Subject Terms: |
*LUNG cancer, *TARGETED drug delivery, *BIODEGRADABLE nanoparticles, *NANOCARRIERS, *GLUCOSE transporters, *NANOPARTICLES analysis, *RADIOACTIVE tracers, *LECTINS, *PLANT lectins |
| Abstract: |
Lung cancer remains the leading cause of cancer death, with an estimated 1.8 million deaths. Triticum-lectin protein, or Triticum-agglutinin (TA), can precisely identify and couple with lectin receptors, glucose transporters, and N-acetyl glucosamine residues overexpressed on lung cancer cells, facilitating receptor-mediated drug targeting. We have developed a site-specific TA-coupled nanoparticle (NPs) of luteolin (TA-conjugated LUT-NPs) to combat benzo(a)pyrene-induced lung carcinogenesis in rats. LUT-NPs and TA-conjugated LUT-NPs were formulated and evaluated for their size, surface morphology, drug loading, entrapment efficiency, stability, in-vivo toxicity, scintigraphic imaging of lungs in rats by 99mTc macro-aggregated albumin lung perfusion, and biodistribution. The formulations were stable and non-toxic. The studies on lung cancer cells showed predominant cellular internalization, cancer cell-specific cytotoxic potential, and apoptotic potential of TA-conjugated LUT-NPs. TA-conjugated LUT-NPs had a superior therapeutic outcome as evidenced by improved histology and lung ultrastructure evaluated by scanning electron microscopy. The study has indicated the excellent potential of TA-conjugated LUT-NPs for site-specific drug delivery in lung carcinogenesis. Triticum-agglutinin surface-modified luteolin-loaded biodegradable nanoparticles in rat pulmonary carcinogenesis [ABSTRACT FROM AUTHOR] |
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