Bibliographic Details
| Title: |
Prevention of the Vertical Transmission of HIV; A Recap of the Journey so Far. |
| Authors: |
Cardenas, Maria Camila1 (AUTHOR), Farnan, Sheila2 (AUTHOR), Hamel, Benjamin L.1 (AUTHOR), Mejia Plazas, Maria Camila2,3 (AUTHOR), Sintim-Aboagye, Elise2 (AUTHOR), Littlefield, Dawn R.2 (AUTHOR), Behl, Supriya2 (AUTHOR), Punia, Sohan2 (AUTHOR), Enninga, Elizabeth Ann L4 (AUTHOR), Johnson, Erica5 (AUTHOR), Temesgen, Zelalem6 (AUTHOR), Theiler, Regan4 (AUTHOR), Gray, Clive M.7 (AUTHOR), Chakraborty, Rana2 (AUTHOR) chakraborty.rana@mayo.edu |
| Source: |
Viruses (1999-4915). Apr2023, Vol. 15 Issue 4, p849. 20p. |
| Subject Terms: |
*HIV infection transmission, *HIV, *HIV-positive women, *AIDS, *SOCIOECONOMIC factors |
| Abstract: |
In 1989, one in four (25%) infants born to women living with HIV were infected; by the age of 2 years, there was 25% mortality among them due to HIV. These and other pieces of data prompted the development of interventions to offset vertical transmission, including the landmark Pediatric AIDS Clinical Trial Group Study (PACTG 076) in 1994. This study reported a 67.5% reduction in perinatal HIV transmission with prophylactic antenatal, intrapartum, and postnatal zidovudine. Numerous studies since then have provided compelling evidence to further optimize interventions, such that annual transmission rates of 0% are now reported by many health departments in the US and elimination has been validated in several countries around the world. Despite this success, the elimination of HIV's vertical transmission on the global scale remains a work in progress, limited by socioeconomic factors such as the prohibitive cost of antiretrovirals. Here, we review some of the key trials underpinning the development of guidelines in the US as well as globally, and discuss the evidence through a historic lens. [ABSTRACT FROM AUTHOR] |
|
Copyright of Viruses (1999-4915) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
