Bibliographic Details
| Title: |
Discovering Nature's Fingerprints: Isotope Ratio Analysis on Bioanalytical Mass Spectrometers. |
| Authors: |
Neubauer, Cajetan1 (AUTHOR) 123caj@gmail.com, Kantnerová, Kristýna1 (AUTHOR), Lamothe, Alexis2 (AUTHOR), Savarino, Joel2 (AUTHOR), Hilkert, Andreas3 (AUTHOR), Juchelka, Dieter3 (AUTHOR), Hinrichs, Kai-Uwe4 (AUTHOR), Elvert, Marcus4 (AUTHOR), Heuer, Verena4 (AUTHOR), Elsner, Martin5 (AUTHOR), Bakkour, Rani5 (AUTHOR), Julien, Maxime6 (AUTHOR), Öztoprak, Merve7 (AUTHOR), Schouten, Stefan7 (AUTHOR), Hattori, Shohei8 (AUTHOR), Dittmar, Thorsten9 (AUTHOR) |
| Source: |
Journal of the American Society for Mass Spectrometry. 4/5/2023, Vol. 34 Issue 4, p525-537. 13p. |
| Abstract: |
For a generation or more, the mass spectrometry that developed at the frontier of molecular biology was worlds apart from isotope ratio mass spectrometry, a label-free approach done on optimized gas-source magnetic sector instruments. Recent studies show that electrospray-ionization Orbitraps and other mass spectrometers widely used in the life sciences can be fine-tuned for high-precision isotope ratio analysis. Since isotope patterns form everywhere in nature based on well-understood principles, intramolecular isotope measurements allow unique insights into a fascinating range of research topics. This Perspective introduces a wider readership to current topics in stable isotope research with the aim of discussing how soft-ionization mass spectrometry coupled with ultrahigh mass resolution can enable long-envisioned progress. We highlight novel prospects of observing isotopes in intact polar compounds and speculate on future directions of this adventure into the overlapping realms of biology, chemistry, and geology. [ABSTRACT FROM AUTHOR] |
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