Bibliographic Details
| Title: |
Acquired Hemophilia A Treated with Recombinant Porcine Factor VIII: Case Report and Literature Review on Its Efficacy. |
| Authors: |
Borro, Matteo1,2 borromatteo@libero.it, Tassara, Riccardo1,2, Paris, Luca1, Artom, Nathan1, Brignone, Marcello1, Rebella, Lara1, Tassara, Rodolfo1 |
| Source: |
Hematology Reports. Mar2023, Vol. 15 Issue 1, p17-22. 6p. |
| Subject Terms: |
*BLOOD coagulation factor VIII, *HEMOPHILIA, *MYOCARDIAL infarction, *PARTIAL thromboplastin time |
| Abstract: |
Acquired hemophilia A (AHA) is a bleeding disorder due to the presence of neutralizing autoantibodies named inhibitors in patients with a previously normal hemostasis. Recent international recommendations suggest the use of bypassing agents or substitutive therapy as the first-line treatment, usually preferring the former. The adequate hemostatic therapy needs an accurate balance between bleeding and thrombotic risks. We report a clinical case of acquired hemophilia A successfully treated with recombinant porcine factor VIII (Susoctocog alfa) as the first-line treatment. Despite the patient having a high-risk thrombotic score and a history of recent myocardial infarction, our experience showed the absence of thrombotic complications related to the use of Susoctocog alfa and a complete restoration of hemostatic parameters. Limited literature is present on the use of recombinant porcine factor VIII as a first-line treatment, and our report supports its use, especially when the thrombotic risk is high. [ABSTRACT FROM AUTHOR] |
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| Database: |
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