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Reference values for interleukin‐6 in the amniotic fluid of asymptomatic pregnant women.

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Title: Reference values for interleukin‐6 in the amniotic fluid of asymptomatic pregnant women.
Authors: del Barco, Ester1 (AUTHOR), Franco‐Jarava, Clara2 (AUTHOR), Vargas, Mireia1 (AUTHOR), Maíz, Nerea1 (AUTHOR), Arevalo, Silvia1 (AUTHOR), Sánchez, Maria Ángeles1 (AUTHOR), Avilés, Maria Teresa1 (AUTHOR), Rodó, Carlota1 (AUTHOR), Mendoza, Manel1 (AUTHOR), Goya, Maria1,3 (AUTHOR) maria.goya@vallhebron.cat, Hernández‐González, Manuel2 (AUTHOR), Carreras, Elena1,3 (AUTHOR)
Source: Acta Obstetricia et Gynecologica Scandinavica. Apr2023, Vol. 102 Issue 4, p480-485. 6p.
Subject Terms: *AMNIOTIC liquid, *AMNIOCENTESIS, *PREGNANT women, *ASYMPTOMATIC patients, *ABORTION, *MATERNAL age
Abstract: Introduction: Nowadays, proinflammatory factors are considered to play an important role in the pathophysiology of threatened preterm labor or chorioamnionitis. The aim of this study was to establish the normal reference range for interleukin‐6 (IL‐6) levels in the amniotic fluid and to identify factors which may alter this value. Material and methods: Prospective study in a tertiary‐level center including asymptomatic pregnant women undergoing amniocentesis for genetic studies from October 2016 to September 2019. IL‐6 measurements in amniotic fluid were performed using a fluorescence immunoassay with microfluidic technology (ELLA Proteinsimple, Bio Techne). Maternal history and pregnancy data were also recorded. Results: This study included 140 pregnant women. Of those, women who underwent termination of pregnancy were excluded. Therefore, a total of 98 pregnancies were included in the final statistical analysis. The mean gestational age was 21.86 weeks (range: 15–38.7) at the time of amniocentesis, and 38.6 weeks (range: 30.9–41.4) at delivery. No cases of chorioamnionitis were reported. The log10 IL‐6 values follow a normal distribution (W = 0.990, p = 0.692). The median, and the 5th, 10th, 90th, and 95th percentiles for IL‐6 levels were 573, 105, 130, 1645, and 2260 pg/mL, respectively. The log10 IL‐6 values were not affected by gestational age (p = 0.395), maternal age (p = 0.376), body mass index (p = 0.551), ethnicity (p = 0.467), smoking status (p = 0.933), parity (p = 0.557), method of conception (p = 0.322), or diabetes mellitus (p = 0.381). Conclusions: The log10 IL‐6 values follow a normal distribution. IL‐6 values are independent of gestational age, maternal age, body mass index, ethnicity, smoking status, parity and method of conception. Our study provides a normal reference range for IL‐6 levels in the amniotic fluid that can be used in future studies. We also observed that normal IL‐6 values were higher in the amniotic fluid than in serum. [ABSTRACT FROM AUTHOR]
Copyright of Acta Obstetricia et Gynecologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Reference values for interleukin‐6 in the amniotic fluid of asymptomatic pregnant women.
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  Data: <searchLink fieldCode="AR" term="%22del+Barco%2C+Ester%22">del Barco, Ester</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Franco‐Jarava%2C+Clara%22">Franco‐Jarava, Clara</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vargas%2C+Mireia%22">Vargas, Mireia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maíz%2C+Nerea%22">Maíz, Nerea</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arevalo%2C+Silvia%22">Arevalo, Silvia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sánchez%2C+Maria+Ángeles%22">Sánchez, Maria Ángeles</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Avilés%2C+Maria+Teresa%22">Avilés, Maria Teresa</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodó%2C+Carlota%22">Rodó, Carlota</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mendoza%2C+Manel%22">Mendoza, Manel</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goya%2C+Maria%22">Goya, Maria</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> maria.goya@vallhebron.cat</i><br /><searchLink fieldCode="AR" term="%22Hernández‐González%2C+Manuel%22">Hernández‐González, Manuel</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carreras%2C+Elena%22">Carreras, Elena</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Obstetricia+et+Gynecologica+Scandinavica%22">Acta Obstetricia et Gynecologica Scandinavica</searchLink>. Apr2023, Vol. 102 Issue 4, p480-485. 6p.
– Name: Subject
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  Data: *<searchLink fieldCode="DE" term="%22AMNIOTIC+liquid%22">AMNIOTIC liquid</searchLink><br />*<searchLink fieldCode="DE" term="%22AMNIOCENTESIS%22">AMNIOCENTESIS</searchLink><br />*<searchLink fieldCode="DE" term="%22PREGNANT+women%22">PREGNANT women</searchLink><br />*<searchLink fieldCode="DE" term="%22ASYMPTOMATIC+patients%22">ASYMPTOMATIC patients</searchLink><br />*<searchLink fieldCode="DE" term="%22ABORTION%22">ABORTION</searchLink><br />*<searchLink fieldCode="DE" term="%22MATERNAL+age%22">MATERNAL age</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: Nowadays, proinflammatory factors are considered to play an important role in the pathophysiology of threatened preterm labor or chorioamnionitis. The aim of this study was to establish the normal reference range for interleukin‐6 (IL‐6) levels in the amniotic fluid and to identify factors which may alter this value. Material and methods: Prospective study in a tertiary‐level center including asymptomatic pregnant women undergoing amniocentesis for genetic studies from October 2016 to September 2019. IL‐6 measurements in amniotic fluid were performed using a fluorescence immunoassay with microfluidic technology (ELLA Proteinsimple, Bio Techne). Maternal history and pregnancy data were also recorded. Results: This study included 140 pregnant women. Of those, women who underwent termination of pregnancy were excluded. Therefore, a total of 98 pregnancies were included in the final statistical analysis. The mean gestational age was 21.86 weeks (range: 15–38.7) at the time of amniocentesis, and 38.6 weeks (range: 30.9–41.4) at delivery. No cases of chorioamnionitis were reported. The log10 IL‐6 values follow a normal distribution (W = 0.990, p = 0.692). The median, and the 5th, 10th, 90th, and 95th percentiles for IL‐6 levels were 573, 105, 130, 1645, and 2260 pg/mL, respectively. The log10 IL‐6 values were not affected by gestational age (p = 0.395), maternal age (p = 0.376), body mass index (p = 0.551), ethnicity (p = 0.467), smoking status (p = 0.933), parity (p = 0.557), method of conception (p = 0.322), or diabetes mellitus (p = 0.381). Conclusions: The log10 IL‐6 values follow a normal distribution. IL‐6 values are independent of gestational age, maternal age, body mass index, ethnicity, smoking status, parity and method of conception. Our study provides a normal reference range for IL‐6 levels in the amniotic fluid that can be used in future studies. We also observed that normal IL‐6 values were higher in the amniotic fluid than in serum. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Acta Obstetricia et Gynecologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/aogs.14524
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      – Code: eng
        Text: English
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        PageCount: 6
        StartPage: 480
    Subjects:
      – SubjectFull: AMNIOTIC liquid
        Type: general
      – SubjectFull: AMNIOCENTESIS
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      – SubjectFull: PREGNANT women
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              Text: Apr2023
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