An Overview of Inter-Tissue and Inter-Kingdom Communication Mediated by Extracellular Vesicles in the Regulation of Mammalian Metabolism.
| Title: | An Overview of Inter-Tissue and Inter-Kingdom Communication Mediated by Extracellular Vesicles in the Regulation of Mammalian Metabolism. |
|---|---|
| Authors: | Castaño, Carlos1,2 (AUTHOR), Novials, Anna1,2 (AUTHOR), Párrizas, Marcelina2 (AUTHOR) badcell@gmail.com |
| Source: | International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 3, p2071. 28p. |
| Subject Terms: | *EXTRACELLULAR vesicles, *METABOLIC regulation, *GUT microbiome, *PANCREATIC beta cells, *TYPE 2 diabetes, *ORGANS (Anatomy) |
| Abstract: | Obesity and type 2 diabetes are associated with defects of insulin action in different tissues or alterations in β-cell secretory capacity that may be triggered by environmental challenges, inadequate lifestyle choices, or an underlying genetic predisposition. In addition, recent data shows that obesity may also be caused by perturbations of the gut microbiota, which then affect metabolic function and energy homeostasis in the host. Maintenance of metabolic homeostasis in complex organisms such as mammals requires organismal-level communication, including between the different organs and the gut microbiota. Extracellular vesicles (EVs) have been identified in all domains of life and have emerged as crucial players in inter-organ and inter-kingdom crosstalk. Interestingly, EVs found in edible vegetables or in milk have been shown to influence gut microbiota or tissue function in mammals. Moreover, there is a multidirectional crosstalk mediated by EVs derived from gut microbiota and body organs that has implications for host health. Untangling this complex signaling network may help implement novel therapies for the treatment of metabolic disease. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: An Overview of Inter-Tissue and Inter-Kingdom Communication Mediated by Extracellular Vesicles in the Regulation of Mammalian Metabolism. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Castaño%2C+Carlos%22">Castaño, Carlos</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Novials%2C+Anna%22">Novials, Anna</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Párrizas%2C+Marcelina%22">Párrizas, Marcelina</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> badcell@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Molecular+Sciences%22">International Journal of Molecular Sciences</searchLink>. Feb2023, Vol. 24 Issue 3, p2071. 28p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22EXTRACELLULAR+vesicles%22">EXTRACELLULAR vesicles</searchLink><br />*<searchLink fieldCode="DE" term="%22METABOLIC+regulation%22">METABOLIC regulation</searchLink><br />*<searchLink fieldCode="DE" term="%22GUT+microbiome%22">GUT microbiome</searchLink><br />*<searchLink fieldCode="DE" term="%22PANCREATIC+beta+cells%22">PANCREATIC beta cells</searchLink><br />*<searchLink fieldCode="DE" term="%22TYPE+2+diabetes%22">TYPE 2 diabetes</searchLink><br />*<searchLink fieldCode="DE" term="%22ORGANS+%28Anatomy%29%22">ORGANS (Anatomy)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Obesity and type 2 diabetes are associated with defects of insulin action in different tissues or alterations in β-cell secretory capacity that may be triggered by environmental challenges, inadequate lifestyle choices, or an underlying genetic predisposition. In addition, recent data shows that obesity may also be caused by perturbations of the gut microbiota, which then affect metabolic function and energy homeostasis in the host. Maintenance of metabolic homeostasis in complex organisms such as mammals requires organismal-level communication, including between the different organs and the gut microbiota. Extracellular vesicles (EVs) have been identified in all domains of life and have emerged as crucial players in inter-organ and inter-kingdom crosstalk. Interestingly, EVs found in edible vegetables or in milk have been shown to influence gut microbiota or tissue function in mammals. Moreover, there is a multidirectional crosstalk mediated by EVs derived from gut microbiota and body organs that has implications for host health. Untangling this complex signaling network may help implement novel therapies for the treatment of metabolic disease. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/ijms24032071 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 28 StartPage: 2071 Subjects: – SubjectFull: EXTRACELLULAR vesicles Type: general – SubjectFull: METABOLIC regulation Type: general – SubjectFull: GUT microbiome Type: general – SubjectFull: PANCREATIC beta cells Type: general – SubjectFull: TYPE 2 diabetes Type: general – SubjectFull: ORGANS (Anatomy) Type: general Titles: – TitleFull: An Overview of Inter-Tissue and Inter-Kingdom Communication Mediated by Extracellular Vesicles in the Regulation of Mammalian Metabolism. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Castaño, Carlos – PersonEntity: Name: NameFull: Novials, Anna – PersonEntity: Name: NameFull: Párrizas, Marcelina IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 16616596 Numbering: – Type: volume Value: 24 – Type: issue Value: 3 Titles: – TitleFull: International Journal of Molecular Sciences Type: main |
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