Bibliographic Details
| Title: |
An Overview of Inter-Tissue and Inter-Kingdom Communication Mediated by Extracellular Vesicles in the Regulation of Mammalian Metabolism. |
| Authors: |
Castaño, Carlos1,2 (AUTHOR), Novials, Anna1,2 (AUTHOR), Párrizas, Marcelina2 (AUTHOR) badcell@gmail.com |
| Source: |
International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 3, p2071. 28p. |
| Subject Terms: |
*EXTRACELLULAR vesicles, *METABOLIC regulation, *GUT microbiome, *PANCREATIC beta cells, *TYPE 2 diabetes, *ORGANS (Anatomy) |
| Abstract: |
Obesity and type 2 diabetes are associated with defects of insulin action in different tissues or alterations in β-cell secretory capacity that may be triggered by environmental challenges, inadequate lifestyle choices, or an underlying genetic predisposition. In addition, recent data shows that obesity may also be caused by perturbations of the gut microbiota, which then affect metabolic function and energy homeostasis in the host. Maintenance of metabolic homeostasis in complex organisms such as mammals requires organismal-level communication, including between the different organs and the gut microbiota. Extracellular vesicles (EVs) have been identified in all domains of life and have emerged as crucial players in inter-organ and inter-kingdom crosstalk. Interestingly, EVs found in edible vegetables or in milk have been shown to influence gut microbiota or tissue function in mammals. Moreover, there is a multidirectional crosstalk mediated by EVs derived from gut microbiota and body organs that has implications for host health. Untangling this complex signaling network may help implement novel therapies for the treatment of metabolic disease. [ABSTRACT FROM AUTHOR] |
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