Bibliographic Details
| Title: |
Metal‐Ligand Cooperativity in MnI‐Catalysed N‐Formylation of Secondary Amides and Lactams Using CO2 at Room Temperature. |
| Authors: |
Chakraborty, Soumi1 (AUTHOR), Nath, Rounak2 (AUTHOR), Kumar Ray, Anuj2 (AUTHOR), Paul, Ankan2 (AUTHOR) rcap@iacs.res.in, Mandal, Swadhin K.1 (AUTHOR) swadhin.mandal@iiserkol.ac.in |
| Source: |
Chemistry - A European Journal. Feb2023, Vol. 29 Issue 7, p1-9. 9p. |
| Subject Terms: |
*MANGANESE catalysts, *TEMPERATURE, *LACTAMS, *CARBON dioxide, *HETEROCYCLIC compounds, *AMIDES, *FORMYLATION |
| Abstract: |
A MnI catalyst featuring redox‐active tridentate phenalenyl (PLY) ligand has been used for catalytic N‐formylation of secondary amides and lactams under 1 atm CO2 as a C1 source at room temperature for the first time. The protocol is applicable to a wide range of secondary amides including heterocycles, bio‐active cinnamide derivatives and the diversification of therapeutic molecules. In‐depth mechanistic investigations based on experimental outcomes and DFT calculations suggested an unconventional metal‐ligand cooperation, where a ligand‐centred radical plays a crucial role in initiating the reaction process. [ABSTRACT FROM AUTHOR] |
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| Database: |
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