Bibliographic Details
| Title: |
Real-Time Documentation of the Effect of Onabotulinumtoxin A Detrusor Injection in OAB Patients—Preliminary Results. |
| Authors: |
Schulte-Baukloh, Heinrich1 (AUTHOR) heinrich.schulte-baukloh@charite.de, Weiß, Catarina2 (AUTHOR), Weinberger, Sarah1 (AUTHOR), Hubatsch, Mandy1 (AUTHOR), Schlomm, Thorsten1 (AUTHOR), Ralla, Bernhard1 (AUTHOR) |
| Source: |
Toxins. Jan2023, Vol. 15 Issue 1, p30. 8p. |
| Subject Terms: |
*INJECTIONS, *OLDER patients, *OVERACTIVE bladder, *OLDER men, *URINATION |
| Abstract: |
Introduction: Detrusor injection with onabotulinumtoxin A (OnabotA-DI) is an established therapy for overactive bladder (OAB). Little is known about the exact onset and course of the effect in the days after the injection therapy. By using a new type of app-controlled automated diary pod, for the first time, the precise onset of the effect of OnabotA-DI can be documented in real time. Materials and methods: Patients due for OnabotA-DI were asked to document voiding 3 days before and up to 3 weeks after therapy using the Diary Pod app. The detrusor injection was performed with onabotulinumtoxin A (Botox®), 100 units, at 20 sites of the detrusor muscle in a standardized manner. Voiding on the injection day itself was not documented. Results: A total of 17 patients (15 women, 2 men; aged 33–83 (mean 64.6; median 70) years) were included in the study. The handling of the Diary Pod app was user-friendly, and elderly patients did not encounter technical problems. The results of patients with reliably documented micturitions showed a continuous reduction in micturition frequency every day from the first day and significantly from day 5. For 24 h voiding, from 12.83 ± 5.54 in the 3 days before injection, the following mean values were found with significant (p < 0.05) changes after the intervention: 9.17 ± 3.19 on day 5, 8.75 ± 3.69 on day 10, 7.17 ± 2.04 on day 15, and 5.75 ± 0.5 on day 20. These changes were in similar proportions during the daytime and nighttime. Conclusions: Contrary to previous knowledge, the effect of the OnabotA-DI set in from the first postoperative days and was reflected a similar extent in day and night micturition. This study is the first to document the onset of action of OnabotA-DI in real time. [ABSTRACT FROM AUTHOR] |
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