Bibliographic Details
| Title: |
Quality of Radiosurgical Plans by Leksell Gamma Knife Perfexion in the Treatment of Meningioma: Comparison between two isodose lines (50% and 75%). |
| Authors: |
Elbaz, Gad1 gadelbaz@azhar.edu.eg, Hendam, Hedaya1, Alashkar, Elsayed M.2, Hamdi, Hussein3, Ereiba, Khiry T.2, Attalla, Ehab4 |
| Source: |
Iranian Journal of Medical Physics / Majallah-I Fīzīk-I Pizishkī-i Īrān. Jan/Feb2023, Vol. 20 Issue 1, p19-30. 12p. |
| Subject Terms: |
*FIVE year plans, *MENINGIOMA, *RADIOSURGERY |
| Abstract: |
Introduction: Radiosurgery is a well-established available technique for treating many diseases and indications. Planning quality assessment is a crucial step in the procedure itself and outcome probabilities; either control or complication probability. Several physical indices and methodology have been developed to describe any plan. Accordingly, plan quality and outcome could be compared with other plans. In current study, the aim was to compare two plans with different isodose line using radiobiological model, tumor control probability (TCP), normal tissue complication probability (NTCP) and plan's physical indices. Material and Methods: The cross-sectional study included 20 patients (5 male and 15 female) with median age of 44 years (21-66) and presented with radiologically diagnosed meningioma. Two radiosurgical forward plans were applied with same marginal dose of 12Gy at two different isodose lines of 50% and 75% isodose alternatively using Leksell Gamma Plan of single session GKS. Dose-Volume Histogram (DVH) was imported to MATLAB to compute TCP, NTCP values at 5 years for each plan, and physical indices such as coverage, selectivity, conformity, heterogeneity, and gradient indices. Results: Median target irradiated volume was 7.5 cm³ (0.588 -23.72). TCP was significantly higher in the plan using 50% isodose line for the marginal dose than that using 75% isodose line (95.05%, 49.44%, p<0.05, Independent Samples t-Test). Brainstem and optic apparatus NTCPs were very low 0.01% (0-0.045%) in the former plan and zero in the later one (p =0.001, Mann-Whitney test). Conclusion: Radiobiological models and physical indices could be used for the optimum plan selection of GKS. [ABSTRACT FROM AUTHOR] |
|
Copyright of Iranian Journal of Medical Physics / Majallah-I Fīzīk-I Pizishkī-i Īrān is the property of Mashhad University of Medical Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
