| Title: |
Drug-related Stevens--Johnson Syndrome and Toxic Epidermal Necrolysis: A Review. |
| Authors: |
Arora, Rohini1 drrohini8@gmail.com, Pande, Rajesh K.1, Panwar, Shikha1, Gupta, Vivek2 |
| Source: |
Indian Journal of Critical Care Medicine. May2021, Vol. 25 Issue 5, p575-579. 5p. 4 Color Photographs, 2 Charts. |
| Subject Terms: |
*TREATMENT of dyspnea, *METHYLPREDNISOLONE, *SKIN diseases, *TOXIC epidermal necrolysis, *CIPROFLOXACIN, *FEVER, *STEVENS-Johnson Syndrome, *EXANTHEMA, *OPHTHALMIC drugs, *ARTIFICIAL respiration, *SILVER nitrate, *DRUG side effects, *AZITHROMYCIN, *CUTANEOUS therapeutics, *ANTHELMINTICS, *DISEASE management, *ANTIBIOTICS, *SURGICAL dressings, *BANDAGES & bandaging |
| Abstract: |
Introduction: Stevens--Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening, allergic reactions affecting the skin and mucous membranes. SJS is considered to be a milder form with less than 10% of body surface area (BSA) involvement. We report successful management of two cases of SJS and TEN. Firstly, a case of a 24-year-old female who presented with rashes over face, chest, and upper limbs after the oral intake of ciprofloxacin and local application of moxifloxacin eye drops. She developed high-grade fever and difficulty in breathing requiring intubation and lung-protective mechanical ventilation and was treated with high-dose methylprednisolone, azithromycin, soframycin skin dressings, and topical ocular antibiotics. Secondly, another case of a 16-year-old female who developed bullous eruptions over the trunk, arms, hands, face, and sole involving 60% of BSA, after oral intake of albendazole. She was diagnosed as TEN and successfully managed with sterile silver nitrate, soframycin dressings, and antibiotics. [ABSTRACT FROM AUTHOR] |
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| Database: |
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