Bibliographic Details
| Title: |
Deep learning radiomics under multimodality explore association between muscle/fat and metastasis and survival in breast cancer patients. |
| Authors: |
Miao, Shidi1 (AUTHOR), Jia, Haobo1 (AUTHOR), Cheng, Ke1 (AUTHOR), Hu, Xiaohui1 (AUTHOR), Li, Jing2 (AUTHOR), Huang, Wenjuan3 (AUTHOR), Wang, Ruitao3 (AUTHOR) ruitaowang@126.com |
| Source: |
Briefings in Bioinformatics. Nov2022, Vol. 23 Issue 6, p1-13. 13p. |
| Subject Terms: |
*DEEP learning, *SARCOPENIA, *RADIOMICS, *BREAST, *CANCER patients, *THORACIC vertebrae, *ADIPOSE tissues |
| Abstract: |
Sarcopenia is correlated with poor clinical outcomes in breast cancer (BC) patients. However, there is no precise quantitative study on the correlation between body composition changes and BC metastasis and survival. The present study proposed a deep learning radiomics (DLR) approach to investigate the effects of muscle and fat on distant metastasis and death outcomes in BC patients. Image feature extraction was performed on 4th thoracic vertebra (T4) and 11th thoracic vertebra (T11) on computed tomography (CT) image levels by DLR, and image features were combined with clinical information to predict distant metastasis in BC patients. Clinical information combined with DLR significantly predicted distant metastasis in BC patients. In the test cohort, the area under the curve of model performance on clinical information combined with DLR was 0.960 (95% CI: 0.942–0.979, P < 0.001). The patients with distant metastases had a lower pectoral muscle index in T4 (PMI/T4) than in patients without metastases. PMI/T4 and visceral fat tissue area in T11 (VFA/T11) were independent prognostic factors for the overall survival in BC patients. The pectoralis muscle area in T4 (PMA/T4) and PMI/T4 is an independent prognostic factor for distant metastasis-free survival in BC patients. The current study further confirmed that muscle/fat of T4 and T11 levels have a significant effect on the distant metastasis of BC. Appending the network features of T4 and T11 to the model significantly enhances the prediction performance of distant metastasis of BC, providing a valuable biomarker for the early treatment of BC patients. [ABSTRACT FROM AUTHOR] |
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