| Title: |
Synthesis of N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine Organic Salts and their Cardiotropic Activity. |
| Authors: |
Mokrov, G. V.1 (AUTHOR) g.mokrov@gmail.com, Bobrovskii, S. I.1 (AUTHOR), Barchukov, V. V.1 (AUTHOR), Kryzhanovskii, S. A.1 (AUTHOR), Tsorin, I. B.1 (AUTHOR), Vititnova, M. B.1 (AUTHOR), Rebeko, A. G.1 (AUTHOR), Gudasheva, T. A.1 (AUTHOR) |
| Source: |
Pharmaceutical Chemistry Journal. Nov2022, Vol. 56 Issue 8, p1049-1053. 5p. |
| Subject Terms: |
*SALTS, *TETRAHYDROISOQUINOLINES, *CITRATES |
| Abstract: |
Organic salts of N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine (I) (succinate ALM-802S and citrate ALM-802C) were obtained. These organic salts were found to retain completely the anti-arrhythmic and anti-ischemic properties of I trihydrochloride (ALM-802) in equimolar doses (2.15 – 2.75 mg/kg, i.v. administration). The new compounds belonged to toxicity class VI (low-toxicity substances). The LD50 values of the organic salts of I recalculated as the base corresponded to that of I trihydrochloride. The pH values of the organic salts of I were significantly higher than that of I trihydrochloride (5.5 – 5.8 vs. 3.5), which eliminated the local irritating action and undesirable organoleptic properties. [ABSTRACT FROM AUTHOR] |
|
Copyright of Pharmaceutical Chemistry Journal is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
