Bibliographic Details
| Title: |
Advances in single-cell nanoencapsulation and applications in diseases. |
| Authors: |
Xue, Ziyang1 (AUTHOR), Mei, Dan1 (AUTHOR), Zhang, Lingling1 (AUTHOR) |
| Source: |
Journal of Microencapsulation. Aug2022, Vol. 39 Issue 5, p481-494. 14p. |
| Subject Terms: |
*RETICULO-endothelial system, *HYDROPHOBIC interactions, *VACCINE manufacturing, *ELECTROSTATIC interaction, *HYDROGEN bonding, *SPRAY drying |
| Abstract: |
Single-cell nanoencapsulation is a method of coating the surface of single cell with nanomaterials. In the early 20th century, with the introduction of various types of organic or inorganic nano-polymer materials, the selection of cell types, and the functional modification of the outer coating, this technology has gradually matured. Typical preparation methods include interfacial polycondensation, complex condensation, spray drying, microdroplet ejection, and layer-by-layer (LbL) self-assembly. The LbL assembly technology utilises nanomaterials with opposite charges deposited on cells by strong interaction (electrostatic interaction) or weak interaction (hydrogen bonding, hydrophobic interaction), which drives compounds to spontaneously form films with complete structure, stable performance and unique functions on cells. According to the needs of the disease, choosing appropriate cell types and biocompatible and biodegradable nanomaterials could achieve the purpose of promoting cell proliferation, immune isolation, reducing phagocytosis of the reticuloendothelial system, prolonging the circulation time in vivo, and avoiding repeated administration. Therefore, encapsulated cells could be utilised in various biomedical fields, such as cell catalysis, biotherapy, vaccine manufacturing and antitumor therapy. This article reviews cell nanoencapsulation therapies for diseases, including the various cell sources used, nanoencapsulation technology and the latest advances in preclinical and clinical research. [ABSTRACT FROM AUTHOR] |
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