Bibliographic Details
| Title: |
Encoding of social novelty by sparse GABAergic neural ensembles in the prelimbic cortex. |
| Authors: |
Zhe Zhao1, Fengqingyang Zeng2, Hanbin Wang3, Runlong Wu4, Liping Chen1, Yan Wu1, Shen Li1, Jingyuan Shao1, Yao Wang3, Junjie Wu2, Zhiheng Feng3, Weizheng Gao3, Yanhui Hu5, Aimin Wang6, Heping Cheng4, Jue Zhang2,3 zhangjue@pku.edu.cn, Liangyi Chen4,7,8 lychen@pku.edu.cn, Haitao Wu1,9,10 wuht@bmi.ac.cn |
| Source: |
Science Advances. 9/2/2022, Vol. 8 Issue 35, p1-14. 14p. |
| Subject Terms: |
*PREMOTOR cortex, *INTERNEURONS, *MEDICAL sciences, *ATMOSPHERIC carbon dioxide, *LIFE sciences |
| Abstract: |
The article discusses research on chemogenetic suppression of social behavior–activated gamma-aminobutyric acid-releasing (GABAergic) neurons in the prelimbic (PrL) area disrupting social novelty behaviors. The new and old mouse exploration–preferred interneurons (NewPNs and OldPNs) of GABAergic interneurons in the PrL were responsible for new and old mouse exploration. Social novelty information may be encoded by the responses of NewPNs and OldPNs in the PrL area via synergistic actions. |
| Database: |
Academic Search Complete |
