| Title: |
Mononucleotide A-repeats may Play a Regulatory Role in Endothermic Housekeeping Genes. |
| Authors: |
Pholtaisong, Jatuphol1 (AUTHOR), Chaiyaratana, Nachol2,3 (AUTHOR), Aporntewan, Chatchawit1,4,5 (AUTHOR) chatchawit.a@chula.ac.th, Mutirangura, Apiwat6 (AUTHOR) |
| Source: |
Evolutionary Bioinformatics. 7/15/2022, Vol. 18, p1-12. 12p. |
| Subject Terms: |
*MICROSATELLITE repeats, *WARM-blooded animals, *HOUSEKEEPING, *SMELL, *SENSORY perception, *GENES |
| Abstract: |
Background: Coding and non-coding short tandem repeats (STRs) facilitate a great diversity of phenotypic traits. The imbalance of mononucleotide A-repeats around transcription start sites (TSSs) was found in 3 mammals: H. sapiens, M. musculus, and R. norvegicus. Principal Findings: We found that the imbalance pattern originated in some vertebrates. A similar pattern was observed in mammals and birds, but not in amphibians and reptiles. We proposed that the enriched A-repeats upstream of TSSs is a novel hallmark of endotherms or warm-blooded animals. Gene ontology analysis indicates that the primary function of upstream A-repeats involves metabolism, cellular transportation, and sensory perception (smell and chemical stimulus) through housekeeping genes. Conclusions: Upstream A-repeats may play a regulatory role in the metabolic process of endothermic animals. [ABSTRACT FROM AUTHOR] |
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