Bibliographic Details
| Title: |
Direct immersion solid-phase microextraction combined with ambient ionization tandem mass spectrometry to rapidly distinguish pesticides in serum for emergency diagnostics. |
| Authors: |
Hung Su1, Hsin-Hua Lin2, Lin-Jhen Su2, Chia-Chen Lin2, Zong-Han Jiang2, Shiang-Jin Chen3, Jentaie Shiea1,4,5, Chi-Wei Lee2 chiweilee1964@gmail.com |
| Source: |
Journal of Food & Drug Analysis. 2022, Vol. 30 Issue 1, p26-37. 12p. |
| Subject Terms: |
*PESTICIDE analysis, *CLINICAL pathology, *HOSPITAL emergency services, *PESTICIDES, *CONVALESCENCE, *MASS spectrometry, *DESCRIPTIVE statistics, *SENSITIVITY & specificity (Statistics), *ACYCLIC acids, *ANALYTICAL chemistry |
| Abstract: |
Despite the fact that carbamates and organophosphates cause acute poisoning via different mechanisms and require disparate management, they are indistinguishable by current clinical assays. Herein, direct immersion solid-phase microextraction (DI-SPME) plus thermal desorption-electrospray ionization tandem mass spectrometry (TD-ESI/MS/MS) was developed to discern them. Both pesticides spiked in human serum were extracted by SPME and analyzed by TD-ESI/MS/MS. This is a promising emergency care platform as rapid analyses could be done in tiny sample volumes with satisfactory recovery (89.46%e116.32%), precision (covariance <20%), sensitivity (LOD <0.1 mg/mL), turnaround time (<5 minutes), and linearity (R² = 0.9827e0.9992) within 0.1-100 mg/mL. [ABSTRACT FROM AUTHOR] |
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| Database: |
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