Bibliographic Details
| Title: |
Short high fat diet triggers reversible and region specific effects in DCX+ hippocampal immature neurons of adolescent male mice. |
| Authors: |
Chiazza, Fausto1,2 (AUTHOR), Bondi, Heather1,2 (AUTHOR), Masante, Irene1,2 (AUTHOR), Ugazio, Federico1,2 (AUTHOR), Bortolotto, Valeria1,2 (AUTHOR), Canonico, Pier Luigi2 (AUTHOR), Grilli, Mariagrazia1,2 (AUTHOR) mariagrazia.grilli@uniupo.it |
| Source: |
Scientific Reports. 11/2/2021, Vol. 11 Issue 1, p1-14. 14p. |
| Subject Terms: |
*HIGH-fat diet, *LOW-fat diet, *NEURONS, *HIPPOCAMPUS (Brain), *BRAIN anatomy, *TEENAGE boys |
| Abstract: |
Adolescence represents a crucial period for maturation of brain structures involved in cognition. Early in life unhealthy dietary patterns are associated with inferior cognitive outcomes at later ages; conversely, healthy diet is associated with better cognitive results. In this study we analyzed the effects of a short period of hypercaloric diet on newborn hippocampal doublecortin+ (DCX) immature neurons in adolescent mice. Male mice received high fat diet (HFD) or control low fat diet (LFD) from the 5th week of age for 1 or 2 weeks, or 1 week HFD followed by 1 week LFD. After diet supply, mice were either perfused for immunohistochemical (IHC) analysis or their hippocampi were dissected for biochemical assays. Detailed morphometric analysis was performed in DCX+ cells that displayed features of immature neurons. We report that 1 week-HFD was sufficient to dramatically reduce dendritic tree complexity of DCX+ cells. This effect occurred specifically in dorsal and not ventral hippocampus and correlated with reduced BDNF expression levels in dorsal hippocampus. Both structural and biochemical changes were reversed by a return to LFD. Altogether these studies increase our current knowledge on potential consequences of hypercaloric diet on brain and in particular on dorsal hippocampal neuroplasticity. [ABSTRACT FROM AUTHOR] |
|
Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
