Bibliographic Details
| Title: |
GRB2 enforces homology-directed repair initiation by MRE11. |
| Authors: |
Zu Ye1, Shengfeng Xu2, Yin Shi3,4, Bacolla, Albino1, Syed, Aleem1, Moiani, Davide1, Chi-Lin Tsai1, Qiang Shen5, Guang Peng6, Leonard, Paul G.7, Jones, Darin E.8, Bin Wang2, Tainer, John A.1 jtainer@mdanderson.org, Ahmed, Zamal1 zahmed@mdanderson.org |
| Source: |
Science Advances. 8/4/2021, Vol. 7 Issue 32, p1-17. 17p. |
| Subject Terms: |
*CHROMATIN, *CHROMATIN-remodeling complexes, *GREEN fluorescent protein, *GENOME editing, *GUANINE nucleotide exchange factors |
| Abstract: |
The article presents a signal transduction research report on GRB2 enforces homology-directed repair initiation by MRE11. Topics include DNA double-strand break (DSB) repair is initiated by MRE11 nuclease for both homology-directed repair (HDR) and alternative end joining (Alt-EJ); and releasing MRE11 to promote efficient HDR over Alt-EJ DSB repair, with implications for genome stability and cancer biology. |
| Database: |
Academic Search Complete |
