| Title: |
Early Reassessment of Total Metabolic Tumor Volume on FDG-PET/CT in Advanced Melanoma Patients Treated with Pembrolizumab Predicts Long-Term Outcome. |
| Authors: |
Vermeulen, Sim1 sim.vermeulen@uzbrussel.be, Awada, Gil1 gil.awada@uzbrussel.be, Keyaerts, Marleen1 marleen.keyaerts@uzbrussel.be, Neyns, Bart1 Bart.Neyns@uzbrussel.be, Everaert, Hendrik1 hendrik.everaert@uzbrussel.be |
| Source: |
Current Oncology. Jun2021, Vol. 28 Issue 3, p1630-1640. 11p. |
| Subject Terms: |
*MELANOMA, *DRUG side effects, *IMMUNE checkpoint inhibitors, *PEMBROLIZUMAB |
| Abstract: |
PD-1 Immune checkpoint inhibitors, such as Pembrolizumab, can have a durable beneficial therapeutic effect in patients with advanced melanoma. However, not all patients will benefit equally from these therapies, and (potentially life-threatening) immune-related adverse events may occur. In this study, we investigate the value of early response assessment by FDG-PET/CT as a biomarker for predicting survival. We identified all patients with advanced melanoma who were treated with Pembrolizumab in our medical center and underwent a baseline and at least one follow-up FDGPET/ CT. The total metabolic tumor volume (TMTV) was calculated, and the evolution was compared to survival parameters. A total of 77 patients underwent a baseline and at least one follow-up FDG-PET/CT, 36 patients had follow-up imaging within 2–4 months, and 21 patients an FDGPET/ CT 5–6 months after baseline. When the TMTV evolution was categorized into two subgroups (stable/decrease versus increase), an association was found between stability or decrease in TMTV and better PFS and OS. A similar trend, however non-significant, was observed at 5–6 months. The evolution in TMTV as assessed by FDG-PET/CT 2–4 months after treatment initiation is associated with long-term outcomes in patients with advanced melanoma treated with Pembrolizumab. [ABSTRACT FROM AUTHOR] |
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| Database: |
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