Bibliographic Details
| Title: |
Analysis of multispectral imaging with the AstroPath platform informs efficacy of PD-1 blockade. |
| Authors: |
Berry, Sneha, Giraldo, Nicolas A., Green, Benjamin F., Cottrell, Tricia R., Stein, Julie E., Engle, Elizabeth L., Haiying Xu, Ogurtsova, Aleksandra, Roberts, Charles, Wang, Daphne, Nguyen, Peter, Qingfeng Zhu, Soto-Diaz, Sigfredo, Loyola, Jose, Sander, Inbal B., Pok Fai Wong, Jessel, Shlomit, Doyle, Joshua, Signer, Danielle, Wilton, Richard |
| Source: |
Science. 6/11/2021, Vol. 372 Issue 6547, p1166-1166. 1p. 1 Color Photograph. |
| Subject Terms: |
*MULTISPECTRAL imaging, *MELANOMA diagnosis, *TUMOR microenvironment, *APOPTOSIS, *BIOMARKERS, *PROTEIN expression, CANCER histopathology |
| Abstract: |
The article provides a summary of a study which applied the AstroPath astronomical algorithms to pathologic analysis of specimens from patients with melanoma using multispectral approaches to image the tumor microenvironment (TME) and substitute cells for stars and galaxies. Topics include the limitations of using immunohistochemistry in assessing anti-programmed cell death-1 (PD-1) protein expression and the impact of high-power field sampling strategies on biomarker performance. |
| Database: |
Academic Search Complete |
