Bibliographic Details
| Title: |
A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury. |
| Authors: |
Okano, Junko1 jokano@belle.shiga-med.ac.jp, Nakae, Yuki2, Nakagawa, Takahiko3, Katagi, Miwako2, Terashima, Tomoya2, Nagakubo, Daisuke4, Nakayama, Takashi5, Yoshie, Osamu6, Suzuki, Yoshihisa1, Kojima, Hideto2 |
| Source: |
Scientific Reports. 3/11/2021, Vol. 11 Issue 1, p1-14. 14p. |
| Subject Terms: |
*BONE marrow transplantation, *KERATINOCYTES, *EFFECT of radiation on skin, *LABORATORY mice, *EPIDERMIS |
| Abstract: |
Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. We had previously reported that bone marrow-derived cells (BMDCs) migrate to the epidermis-dermis junction in response to IR, although their role remains unknown. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery. [ABSTRACT FROM AUTHOR] |
|
Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
