C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility.

Bibliographic Details
Title:	C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility.
Authors:	Fumagalli, Laura^1,2, Young, Florence L.³, Boeynaems, Steven⁴, De Decker, Mathias^1,2, Mehta, Arpan R.^5,6,7,8, Swijsen, Ann^1,2, Fazal, Raheem^1,2, Wenting Guo^1,2,9, Moisse, Matthieu^1,2, Beckers, Jimmy^1,2, Dedeene, Lieselot^1,2,10,11,12, Selvaraj, Bhuvaneish T.^5,6,8, Vandoorne, Tijs^1,2, Madan, Vanesa³, van Blitterswijk, Marka¹³, Raitcheva, Denitza¹⁴, McCampbell, Alexander¹⁴, Koen Poesen^10,12, Gitler, Aaron D.⁴, Koch, Philipp^15,16
Source:	Science Advances. 4/7/2021, Vol. 7 Issue 15, p1-20. 20p.
Subject Terms:	AXONAL transport, AMYOTROPHIC lateral sclerosis, TUBULINS, GREEN fluorescent protein, NUCLEOCYTOPLASMIC interactions, NUCLEAR transport (Cytology), *HEAT shock proteins
Abstract:	The article presents a study of the effect of C9orf72-derived arginine-containing dipeptide repeats (DPR) on axonal transport machinery and microtubule-based motility in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Topics discussed include the link between arginine-rich DPR and kinesin-1,dynein and microtubules, importance of axonal organelles and macromolecules transport for neuronal homeostasis, and other factors that might affect trafficking defects.
Database:	Academic Search Complete