Bibliographic Details
| Title: |
First case of Whipple's disease successfully treated with tigecycline. |
| Authors: |
Foteinogiannopoulou, Kalliopi1 drfpopi@hotmail.com, Mouzas, Ioannis2, Tzardi, Maria3, Orfanoudaki, Eleni1, Theodoraki, Eirini1, Kofteridis, Diamantis4 |
| Source: |
Germs. Mar2021, Vol. 11 Issue 1, p105-110. 6p. |
| Subject Terms: |
*TIGECYCLINE, *DIAGNOSIS, *NATURAL immunity, *WEIGHT loss, *POLYMERASE chain reaction |
| Abstract: |
Introduction: Whipple's disease is a rare chronic infectious disease caused by Tropheryma whipplei. The infection mainly affects the small intestine of middle-aged patients, approximately three times more often in males than in females causing malabsorption and excessive weight loss but other organs may be affected as well. Case report: We describe a case of a 42-year-old woman with a history of chronic diarrhea and weight loss evolving for at least the last 6 years. The diagnosis of Whipple's disease was confirmed by histopathological examination of duodenal biopsy samples with Periodic acid-Schiff positive macrophages and by polymerase chain reaction technique detecting the DNA of Tropheryma whipplei. The patient was commenced on several antimicrobials including beta-lactams and co-trimoxazole but she did not improve. Finally, after-long lasting i.v. tigecycline 100 mg BID she was commenced on p.o. doxycycline along with hydroxychloroquine 200 mg TID for one year and after by p.o. doxycycline alone. Discussion: The intriguing thing with this case was not only the natural resistance to co-trimoxazole but that the infection was controlled empirically with long-lasting i.v. tigecycline since several failed attempts to discontinue i.v. treatment followed. This might be due to erratic absorption of oral drugs due to gut inflammation. Conclusions: To our knowledge, this is the first case of Whipple's disease successfully treated with long-lasting induction parenteral tigecycline followed by p.o. doxycycline along with hydroxychloroquine for one year and after by p.o. doxycycline alone. [ABSTRACT FROM AUTHOR] |
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| Database: |
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