Bibliographic Details
| Title: |
Antiinflammation effect of garciana mangostana pericarp extract in albino mice skin induced by 12-0-tetradecanoylphorbol-13-acetate. |
| Authors: |
Mokoagow, Kirana Prasanty1 kiranakiranaw@gmail.com, Djawad, Khairuddin1, Wahab, Siswanto1, Bahar, Burhanuddin2, Miskad, Upik Andriani3, Waspodo, Nurelly1 |
| Source: |
EurAsian Journal of Biosciences. Aug-Dec2020, Vol. 14 Issue 2, p5815-5821. 7p. |
| Subject Terms: |
*MANGOSTEEN, *BIOACTIVE compounds, *IMMUNE response, *PERICARP, *INFLAMMATION |
| Abstract: |
Background: Mangosteen (Garciana mangostana Linn.) is a tropical fruit that is most commonly found in Southeast Asia. Mangosteen skin has been reported to contain various beneficial bioactive components such as anti-inflammatory effects. The skin not only serves as a physical and chemical barrier but also as a competent immune system that elicits both innate and adaptive immune responses to pathogens or other inflammatory damages. 12-O-tetradecanoylphorbol-13-acetate (TPA) is a protein kinase activator that induces inflammatory skin reactions. In this study, we investigated the effect of mangosteen pericarp extract as an inhibitory agent for acute inflammatory responses on TPA-induced albino mice skin inflammation. Materials and Methods: Hematoxylin & Eosin staining histopathology was used to analyze neutrophil infiltration, epidermal thickness, edema, and vascular permeability. Results: Garciana mangostana pericarp extract cream showed reduced TPA-induced neutrophil infiltration and epidermal thickness. The best concentration is both at 20% and 10%, respectively. Conclusion: Our study suggests that the naturally derived Garcinia mangostana pericarp extract cream provides an acute anti-inflammatory effect on the skin. [ABSTRACT FROM AUTHOR] |
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| Database: |
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