Bibliographic Details
| Title: |
The clonal repopulation of HSPC gene modified with anti-HIV-1 RNAi is not affected by preexisting HIV-1 infection. |
| Authors: |
Suryawanshi, Gajendra W.1,2, Khamaikawin, Wannisa2,3, Jing Wen1,2, Shimizu, Saki3, Arokium, Hubert1,2, Yiming Xie1,2, Wang, Eugene1, Shihyoung Kim4,5,6, Hyewon Choi1,2,4, Chong Zhang7, Hannah Yu4,5,6, Presson, Angela P.7,8, Kim, Namshin9, Dong-Sung An2,3, Chen, Irvin S. Y.1,2,10 syuchen@mednet.ucla.edu, Sanggu Kim4,5,6 |
| Source: |
Science Advances. 7/24/2020, Vol. 6 Issue 30, p1-13. 13p. |
| Subject Terms: |
*HEMATOPOIESIS, *HIV infections, *HIGHLY active antiretroviral therapy, *PYROSEQUENCING, *BUSULFAN |
| Abstract: |
In this article the author offers information of the clonal repopulation of hematopoietic stem/progenitor cell (HSPC) gene which is modified with anti–HIV-1 RNAi and is not affected by preexisting HIV-1 infection. Topics discussed impact of a preexisting HIV-1 infection on engraftment and clonal repopulation of HSPCs remains poorly understood; and data demonstrate that, the substantial impact of HIV-1 infection on CD4+ T cells, supporting the use of HSPC transplant for anti-HIV treatment. |
| Database: |
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